15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics

Publication date: Available online 19 May 2017 Source:Pathology - Research and Practice Author(s): V. Krenn, G. Perino, W. Rüther, V.T. Krenn, M. Huber, T. Hügle, A. Najm, S. Müller, F. Boettner, F. Pessler, W. Waldstein, J. Kriegsmann, R. Casadonte, T. Häupl, S. Wienert, M.G. Krukemeyer, S. Sesselmann, S. Sunitsch, R. Tikhilov, L. Morawietz The histopathological synovitis score evaluates the immunological and inflammatory changes of synovitis in a graduated manner generally customary for diagnostic histopathological scores. The score results from semiquantitative evaluation of the width of the synovial surface cell layer, the cell density of the stroma and the density of the inflammatory infiltration into 4 semiquantitative levels (normal 0, mild 1, moderate 2, severe 3). The addition of these values results in a final score of 0 to 9 out of 9. On the basis of this summation the condition is divided into low-grade synovitis and high-grade synovitis: A synovitis score of 1 to≤4 is called low-grade synovitis (arthrosis-associated/OA synovitis, posttraumatic synovitis, meniscopathy-associated synovitis and synovitis with haemochromatosis). A synovitis score of≥5 to 9 is called high-grade synovitis (rheumatoid arthritis, psoriatic arthritis, Lyme arthritis, postinfection/reactive arthritis and peripheral arthritis with Bechterew's disease). By means of the synovitis score it is therefore possible to distinguish between degenerative/posttraumatic diseas...
Source: Pathology Research and Practice - Category: Pathology Source Type: research

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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: L.A. Times - Health - Category: Consumer Health News Source Type: news
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