Scientists One Step Closer To 3-D-Printed Ovaries To Treat Infertility
Researchers printed gelatin scaffolds into which they placed ovarian tissue, and then implanted the new organs in mice. Three out of seven female mice produced healthy offspring using the technology.(Image credit: Northwestern University Feinberg School of Medicine)
AbstractPurpose of ReviewOpioids are the cornerstone for pain treatment with significant recent increases in the number of prescriptions. Sexual dysfunction (SD) is a major side effect of opioid therapy. The goal of this review is to examine the current literature on the effects of opioids on male SD (erectile dysfunction [ED], hypogonadism, ejaculatory dysfunction) and infertility.Recent FindingsHigh prevalence of SD exists in men with opioid use as compared to the general population, with an abundance of evidence suggesting an association between opioid use and ED and hypogonadism. There appears to be a role for testoste...
AbstractTesticular apoptotic cell death (TACD) contributes to diabetes mellitus (DM)-induced male infertility. MicroRNA-34a (miR-34a) is a pro-apoptotic RNA that targets sirtuin 1 (SIRT1) which provides protection against complications of (DM). However, the specific role of miR-34a in (DM)-induced TACD is unknown. MiR-34a targetsSirt1 mRNA, resulting in apoptosis. However, whether or not SIRT1 is a major target of miR-34a in (DM)-induced TACD is unclear. The present study aimed to define the role of miR-34a/SIRT1 in (DM)-induced TACD. C57BL/6 male mice were induced to (DM) by streptozotocin, for a period of 24 ...
CONCLUSIONS: Unbalanced production of Cho signal in the follicular fluid may have occurred secondary to membrane damage of cumulus-oocyte-complexes due to CC therapy. PMID: 30024629 [PubMed - in process]
UK campaigners Fertility Network UK say the invention of IVF is less of an achievement because not enough people have full access to the treatment which helps infertile people to conceive.
ConclusionsOur finding of an increased risk of HGSC associated with PID lends support to the hypothesis that inflammatory processes may be involved in the etiology of HGSC.
Unfortunately, the first author name was incorrectly published in the original publication. The complete correct name should read as follows.
ConclusionsAge of the mother, outcome of the first pregnancy, and treatment factors affect the length of the interpregnancy interval. Because short IPI has been associated with poor outcomes, women who are at risk for short IPI should be counseled about these outcome risks.
Publication date: Available online 18 July 2018Source: PeptidesAuthor(s): Sevil Arabaci Tamer, Alper Yildirim, M. Kutay köroğlu, Özge Çevik, Feriha Ercan, Berrak Ç. YeğenAbstractTesticular torsion causes ischemia-reperfusion injury and an increased risk of infertility. Nesfatin-1 is a novel peptide with antioxidant, anti-inflammatory and anti-apoptotic properties. In the present study, we aimed to investigate the putative beneficial effects of nesfatin-1 on oxidative injury and impaired testicular function induced by testis torsion. Under anesthesia, male Sprague-Dawley rats (180-230 g; n = ...
Conditions: Infertility, Female; Endometrium Intervention: Procedure: UC-MSCs therapy Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Acephalic spermatozoa syndrome is a severe teratozoospermia that leads to male infertility. Our previous work showed that biallelic SUN5 mutations are responsible for acephalic spermatozoa syndrome in about half of affected individuals, while pathogenic mechanisms in the other individuals remain to be elucidated. Here, we identified a homozygous nonsense mutation in the testis-specific gene PMFBP1 using whole-exome sequencing in a consanguineous family with two infertile brothers with acephalic spermatozoa syndrome.