An update on the animal models in hyperuricaemia research.

An update on the animal models in hyperuricaemia research. Clin Exp Rheumatol. 2017 May 08; Authors: Zhu Y, Peng X, Ling G Abstract Hyperuricaemia is a metabolic disease caused by purine metabolic abnormalities, mainly due to the increased formation or reduced excretion of uric acid. In recent years, it has been proved that hyperuricaemia is an important risk factor for chronic kidney disease (CKD) and cardiovascular disease, and it also takes part in the pathophysiology of metabolic syndrome. In addition, more attention has been concentrated on the pathogenesis or treatment of hyperuricaemia. Since establishing an animal model on hyperuricaemia is the foundation for further researches, several methods to establish the hyperuricaemia model have been developed. In this article, remarkable progress on the modelling approach are summarised, and a comparison study on different methods of developing hyperuricaemia animal models was conducted. PMID: 28516889 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research