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SPECT links omega-3 with Alzheimer's prevention

SPECT images of the brain show that a diet containing omega-3 fatty acids increases...Read more on AuntMinnie.comRelated Reading: Alzeca touts study of MRI agent in Alzheimer's FDG-PET outshines SPECT for Alzheimer's disease Dementia link? SPECT finds brain changes in football players MRI shows fish-filled diet helps lower Alzheimer's risk SPECT ties functional brain abnormalities to fibromyalgia
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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The news about mechanistic therapies in neurodegeneration has been generally rather glum, particularly with the disappointing results of trials targeting β-secretase for Alzheimer's disease. However, in my view, the most important development in neurodegeneration research in 2017 has been the introduction of successful gene-based therapies for spinal muscular atrophy, which is caused by mutations in the SMN1 gene.1,2 One phase 1–2 trial1 assessed the effect of injection of adeno-associated virus carrying SMN1 cDNA, and a phase 3 trial2 assessed intrathecal injection of an antisense oligonucleotide (nusinersen) t...
Source: Lancet Neurology - Category: Neurology Authors: Tags: 2017 Round-up Source Type: research
Genome-wide association studies (GWAS) have made substantial contributions to our understanding of complex neurodegenerative diseases. For example, the largest GWAS of Alzheimer's disease so far has identified 19 loci in addition to APOE and revealed key pathways of disease pathogenesis, including inflammation and immune response, lipid metabolism, and endocytosis.1 Similarly, two GWAS of Parkinson's disease have uncovered 41 loci and suggested a major role of autophagy and lysosomal biology in Parkinson's disease risk.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research
Your Editorial highlighted the need of trials on dementia prevention, and welcomed the launch of World Wide Fingers WW-FINGERS),1 but did not provide details on this initiative. WW-FINGERS springs from the successful experience of the Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER),2 a landmark trial that showed that a multidomain lifestyle intervention, based on simultaneous management of several vascular and lifestyle-related risk factors for dementia and Alzheimer's disease (AD), can benefit cognition in people aged 60 –77 years with high risk of dementia.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Correspondence Source Type: research
Beyond Memories is the fourth instalment in a series of exhibitions by the London Brain Project, a collective of scientists and artists who aim to engage and educate the public about neurological diseases though art. Beyond Memories specifically aims to illuminate lesser known aspects of dementia, and to dispel stereotypes surrounding the subject. London Brain Project co-director Georgia Pitts says, “I think it's important for people to know that ‘dementia’ itself isn't a disease. It's a word used to describe a set of symptoms caused by different neurological disorders…many people don't know that, ...
Source: Lancet Neurology - Category: Neurology Authors: Tags: In Context Source Type: research
Despite the small sample size for a genome-wide association study, and acknowledging the potential biases from ascertaining samples from multiple locations, we present the most comprehensive and well powered genetic study in dementia with Lewy bodies so far. These data show that common genetic variability has a role in the disease.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Articles Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
The understanding of cognitive decline and dementia has advanced considerably over the past decade, despite the drug industry’s numerous failed attempts to develop a drug to treat the condition. But a successful effort at preventing, even reversing, cognitive decline and dementia requires a multi-faceted approach that involves diet, correction of nutritional deficiencies, exercise, learning new skills, and a number of other efforts. This is the first in a series of videos exploring all these issues, all designed to arm you with the best information available. The remainder of the series will be posted on the Undoctor...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle alzheimer alzheimer's cognition cognitive dementia diy health Dr. Davis Wheat Belly Total Health Source Type: blogs
CONCLUSIONS: S-adenosylmethionine holds promise as a treatment for multiple neuropsychiatric conditions, but the body of evidence has limitations. The encouraging findings support further study of SAMe in both psychiatric and comorbid medical illnesses. PMID: 28682528 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insom...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research
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