Gastric Cancer as Preventable Disease

Gastric cancer (GC), one of the five most common causes of cancer death, is associated with a 5-year overall survival rate less than 30%. A minority of cancers occurs as part of syndromic diseases; more than 90% of adenocarcinomas are considered as the ultimate consequence of a longstanding mucosal inflammation. H. pylori infection is the leading etiology of non-self-limiting gastritis, which may result in atrophy of the gastric mucosa and impaired acid secretion. Gastric atrophy establishes a field of cancerization prone to further molecular and phenotypic changes, possibly resulting in cancer growth.

Source: Clinical Gastroenterology and Hepatology - May 19, 2017 Category: Gastroenterology Authors: Massimo Rugge, Robert M. Genta, Francesco Di Mario, Emad M. El-Omar, Hashem B. El-Serag, Matteo Fassan, Richard H. Hunt, Ernst J. Kuipers, Peter Malfertheiner, Kentaro Sugano, David Y. Graham Source Type: research