T-tubule remodelling disturbs localized β 2 -adrenergic signalling in rat ventricular myocytes during the progression of heart failure

ConclusionAlthough changes in T-tubule structure and β2AR-mediated cAMP signalling are significant even at 4-week post-MI, progression to the HF phenotype is not linear. At 8-week post-MI the loss of β2AR-mediated cAMP is temporarily reversed. Complete disorganization of β2AR-mediated cAMP signalling due to changes in functional receptor localization and cellular structure occurs at 16-week post-MI.
Source: Cardiovascular Research - Category: Cardiology Source Type: research