Obstetric and neonatal outcomes of pregnancies conceived after preimplantation genetic diagnosis: cohort study and meta-analysis

This study compares outcome of singleton and twin clinical pregnancies conceived after fresh embryo transfers of PGD (n = 89) and matched intracytoplasmic sperm injection (ICSI) pregnancies (n = 166). The study was carried out in a single university affiliated centre. Because of the paucity of available data, a literature-based meta-analysis of studies comparing neonatal outcome of PGD and ICSI pregnancies was also conducted. In the retrospective cohort study, obstetric and neonatal outcome were available in 67 PGD and 118 ICSI pregnancies. Perinatal outcomes were comparable between PGD and ICSI pregnancies. Meta-analysis revealed similar outcomes, except for higher rate of low birth weight (<2500 g) neonates in ICSI twin pregnancies (RR 0.86, 95% CI 0.74 to 1.0). Mean birth weight, gestational age at birth, pre-term deliveries (<37 weeks) and malformations were all comparable. In this cohort study and subsequent meta-analysis, no association was found between PGD conceived pregnancies and risks of adverse neonatal or obstetrical outcomes compared with ICSI pregnancies. Hence, blastomere biopsy for PGD does not seem to increase the risk for adverse perinatal outcome compared with ICSI pregnancies.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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This study aimed to evaluate metaphase II (MII) oocyte competence in terms of fertilization, embryo development and cycle outcomes, according to the oocyte maturity ratio.DesignCouples treated by intracytoplasmic sperm injection (ICSI) between 1993 and 2017 with female partners ≤35 years old were included. Cycles were divided into four groups according to proportion of MII oocytes at the time of retrieval: optimal (76–100%), adequate (51–75%), partial (26–50%) and minimal (1–25%).ResultsA total of 7672 ICSI cycles (optimal: 4838; adequate: 2252; partial: 518; minimal oocyte maturity: 64) were inc...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Conclusion(s)Microfluidic selection yielded spermatozoa with optimal genomic integrity and improved chances of obtaining a euploid conceptus.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Abstract Intracytoplasmic sperm injection (ICSI) is performed in cases of infertility by injecting a motile and morphologically normal sperm cell under a routine ×400 magnification at which is hard to distinguish morphologically healthy sperm. Recently, the use of high-powered differential interference contrast optics gave the opportunity to select a sperm under ultra-high magnification of ×10,160. The aim of the present study was to evaluate the efficacy of the intracytoplasmic morphologically selected sperm injection (IMSI) technique in different infertility populations undergoing ICSI. Main outcome ...
Source: Zygote - Category: Reproduction Medicine Authors: Tags: Zygote Source Type: research
ConclusionsThis sequence variation of DEFB126 may impair male reproductive function and can be related to male infertility. Interestingly, males with the del/del genotype have a normal spermiogram; however, their spermatozoa are evidently functionally impaired, which can affect IUI treatment outcome, but not treatment by IVF/ICSI.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
We report an infertile male with NOA, a solitary left testicle and a left clinical varicocele. The patient first underwent an extensive left microTESE. No spermatozoa were seen on initial microscopic evaluation but after an extensive search, spermatozoa were identified. ICSI did not result in pregnancy. Fifteen months after the microTESE, the patient underwent a left microsurgical varicocelectomy. A semen analysis post-varicocelectomy revealed the presence of sperm.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
AbstractPurposeTo determine the consequences of an altered sperm fluorescence in situ hybridization (FISH) result for ART outcomes and the indications for a sperm FISH analysis.MethodsData from 439 infertile men were collected. Bivariate analyses were performed to determine the association of men ’s age, seminal alterations, and sperm FISH indication, with the incidence of X, Y, 13, 18, and 21 sperm chromosomal abnormalities. A multivariate logistic regression analysis was performed to establish the most predictive variables for altered sperm FISH. Results from the IVF/ICSI cycles were col lected for 248 out of 439 p...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Cochrane Overviews bring together the findings from multiple reviews and one of the largest, first published in September 2013, was updated and republished in May 2018. Cindy Farquhar, from the Department of Obstetrics and Gynaecology at the University of Auckland in New Zealand describes this enormous volume of evidence for assisted reproduction." Infertility is defined as failure to conceive after one year of trying. Up to one in six couples will experience this at some point in their lives and many will seek fertility treatment in the form of assisted reproduction. When they do so, they will hope that they are gett...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
The objective of this study is to analyze the potential of immature, denuded, post-GVBD (germinal vesicle breakdown) oocytes (including prometaphase I, metaphase I, and prometaphase II stages) to result live birth after in vitro maturation. Furthermore, we compared two culture media to identify which of them provides better reproductive outcomes when used for in vitro maturation.MethodsWe performed a retrospective cohort study including 4022 IVF-ICSI (in vitro fertilization-intracytoplasmic sperm injection) cycles between 2011 and 2015. A total of 4450 immature post-GVBD oocytes from 1442 cycles were cultured in vitro; of ...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Conclusions: Female obesity adversely affected the CLBR after utilizing the viable embryos after first oocytes retrieval.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 6 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Chun-I Lee, Chien-Hong Chen, Chun-Chia Huang, En-Hui Cheng, Hsiu-Hui Chen, Su-Ting Ho, Pin–Yao Lin, Maw-Sheng Lee, Tsung-Hsien LeeAbstractResearch questionAre the morphokinetics of euploid blastocysts evaluated by a generally applicable algorithm associated with the clinical outcomes of single-embryo transfer (SET)?DesignTime-lapse microscopy was used to compare morphokinetic variables between expanded blastocysts derived from preimplantation genetic testing for aneuploidy cycles using high-resolution next-generation seque...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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