Endothelial Nox1 Oxidase Assembly in Human Pulmonary Arterial Hypertension; Driver of Gremlin1-Mediated Proliferation

Conclusion: Together these data support a Nox1-Gremlin1 signaling axis in pulmonary vascular endothelium that is likely to contribute to pathophysiological endothelial proliferation and the progression of PAH. The findings also support targeting of Nox1 as a viable therapeutic option to combat PAH.

Source: Clinical Science - May 18, 2017 Category: Biomedical Science Authors: Al Ghouleh, I., Sahoo, S., Meijles, D. N., Amaral, J. H., de Jesus, D. S., Sembrat, J., Rojas, M., Goncharov, D. A., Goncharova, E. A., Pagano, P. J. Tags: PublishAheadOfPrint Source Type: research