3D Printing from Cardiac Computed Tomography for Procedural Planning

This article summarizes the uses of 3D-printed models in preoperative cardiac procedure planning and intraprocedural navigation during surgeries organized on a case-by-case basis.Recent FindingsThe 3D models have recently been shown to aid in a variety of procedures. Some of these include valvular replacement or repair, management of paravalvular leaks, left atrial appendage closure, myectomy in hypertrophic cardiomyopathy, cardiac aneurysm repair, tumor resection, and surgical planning in congenital heart lesions.SummaryWe anticipate that 3D models will become more accessible, and their utilization will increase in the near future. However, CT-based 3D printing will require further assessment with multicenter-based studies. Multicenter explorations will allow for consensus and standardization of such potentially useful tools, given the vast availability of printing and imaging techniques currently available.
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

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Publication date: Available online 10 September 2019Source: Diagnostic and Interventional ImagingAuthor(s): E. Deborde, B. Dubourg, S. Bejar, A.-C. Brehin, S. Normant, P. Michelin, J.-N. DacherAbstractPurposeTo evaluate the potential of non-contrast myocardial T1 mapping on cardiovascular magnetic resonance examination (CMR) in differentiating patients with Fabry disease (FD) from those with hypertrophic cardiomyopathy (HCM) and healthy control subjects.Materials and methodsSeventeen patients with FD (8 men, 9 women; mean age, 48  ± 18 [SD] years; [range: 19–73 years]; 53% with left ventricular hyper...
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
Reducing the SAM is a key way of resolving LVOT obstruction in surgery for HOCM. We developed a new technique using a floating stitch on the anterior mitral leaflet (AML). It is applied just to the middle of the tip of the AML and fixed to the annuloplasty ring at the middle of the posterior annulus. The AML is prevented from touching the interventricular septum and SAM can theoretically be solved.
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ADULT - Surgical Technique Source Type: research
ConclusionIn conclusion, native T1 values were significantly different between NIC patients and controls. Native T1 mapping may be a useful noninvasive method to detect diffuse myocardial fibrosis in NIC patients.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Abstract Hypertrophic Cardiomyopathy (HCM) is the most frequent primary cardiomyopathy, a genetic disease affecting 1:500 of the general population. Integrated multimodality imaging - using transthoracic echocardiography, 2D/3D-transesophageal echocardiography, stress-echocardiography and cardiac magnetic resonance succeeds in providing answers to management questions, leading to standardized protocols. If the late 90s came with the news of a non-surgical method to treat the obstruction in HCM patients, nowadays, it is increasingly evident the septal ablation is not able to address all the mechanisms of the LVOT g...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
The objective of this study was to evaluate the genotype-phenotype relation in HCM patients and to construct a score to predict the genetic yield based to improve counseling. Unrelated HCM patients who underwent genetic testing were included in the analysis. Multivariate logistic regression was performed to identify variables that predict a positive genetic test. A weighted score was constructed based on the odds ratios. In total, 378 HCM patients were included of whom 141 carried a mutation (global yield 37%), 181 were mutation negative and 56 only carried a variant of unknown significance. We identified age at diagnosis
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
CONCLUSIONS: Our results showed fatal HCM harbored mutations of Thr446Pro and Phe468Leu in the MYH7 gene. It is significant for clinical and forensic medicine to further explore the functions and detailed mechanisms of these mutations. PMID: 31503054 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
AbstractHydroxychloroquine (HCQ) is a well ‐established and effective immunomodulatory therapy for systemic lupus erythematosus and other autoimmune diseases. While retinal toxicity is a well‐recognized complication, cardiotoxicity is lesser known. This case consists of a 63‐year‐old Filipina on chronic HCQ treatment that led to seve re biventricular hypertrophy, increased filling pressure, systemic and pulmonary hypertension, and elevated brain natriuretic peptide. Genetic testing ruled out lysosomal storage disorders but revealed five rare variants of uncertain significance, including one that was temporarily re...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
AbstractWe aim to validate echocardiographic left ventricular (LV) mass (echoLVM) in sixty-one patients with hypertrophic cardiomyopathy (HCM), using cardiac magnetic resonance measures (cmrLVM) as gold standard. cmrLVM was calculated using LV short-axis images, from base to apex, whereas echoLVM by LV epicardial minus LV endocardial volumes in 4 and 2 chamber views, using Simpson disk summation; trabeculae and papillary muscle were excluded in both cmrLVM and echoLVM. cmrLVM and echoLVM were not different by pairedt test (145  ± 66 vs 147 ± 61;p = 0.240), and their c...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
ConclusionsPlasma GDF11 was not different between cats with HCM/HOCM and cats with normal cardiac structure regardless of age. Plasma GDF8 was decreased in cats with CHF compared to cats with normal cardiac structure and cats with asymptomatic HCM/HOCM, suggesting a possible role in CHF development.
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research
Source: Acta Clinica Belgica - Category: General Medicine Authors: Source Type: research
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