Resistance of non-fermenting Gram-negative bacilli isolated from blood cultures from an emergency hospital

Conclusion: Screening of resistant NFGNB isolated, as well as greater attention to hospital-acquired infection control practices and epidemiological surveillance systems, in addition to continued care with regard to the targeted use of antibiotics can contribute to successful this battle against infections by these microorganisms.RESUMO Introdu ção: Os bacilos Gram-negativos não fermentadores (BGNNF) são um grupo heterogêneo de microrganismos que não possuem a capacidade de fermentar carboidratos como forma de obtenção de energia. Possuem mais de 120 espécies classificadas como patogênicas, destacando-se entre elas Pseudomonas ae ruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia e Burkholderia cepacia. As infecções causadas por esses microrganismos são, em sua maioria, adquiridas nos ambientes hospitalares, já que se tratam de patógenos oportunistas, estando entre as bactérias de maior relevância clínic a e epidemiológica. Objetivo: Este trabalho avaliou o perfil de resistência dos BGNNF isolados de hemoculturas em um hospital de emergência na cidade de Caruaru, no Agreste Pernambuco (PE), Brasil. Métodos: As cepas presentes nas hemoculturas foram isoladas nos meios de cultura ágar MacConkey e ágar Triple Sugar Iron (TSI). As amostras também foram submetidas ao teste de oxidase e ao teste de res...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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Lipika Singhal, Parvinder Kaur, Vikas GautamIndian Journal of Medical Microbiology 2017 35(4):469-479Stenotrophomonas maltophilia, once regarded as an organism of low virulence, has evolved as a significant opportunistic pathogen causing severe human infections in both hospital and community settings, especially amongst highly debilitated patients. Globally, S. maltophilia ranks third amongst the four most common pathogenic non-fermenting Gram-negative bacilli (NFGNBs), others being Pseudomonas aeruginosa, Acinetobacter baumannii and Burkholderia cepacia complex (Bcc). The worth of accurate identification of S. maltophilia...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Therapies for multidrug resistant and extensively drug-resistant non-fermenting gram-negative bacteria causing nosocomial infections: a perilous journey toward "molecularly targeted" therapy. Expert Rev Anti Infect Ther. 2018 Jan 09;: Authors: El Chakhtoura NG, Saade E, Iovleva A, Yasmin M, Wilson B, Perez F, Bonomo RA Abstract INTRODUCTION: Non-fermenting Gram-negative bacilli are at the center of the antimicrobial resistance epidemic. Acinetobacter baumannii and Pseudomonas aeruginosa are both designated with a threat level to human health of "serious" by the Centers for Disease C...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Abstract The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-649266), was determined against a 2014-2016, 52-country, worldwide collection of clinical isolates of carbapenem-non-susceptible Enterobacteriaceae (n=1,022), multidrug-resistant (MDR) Acinetobacter baumannii (n=368), MDR Pseudomonas aeruginosa (n=262), Stenotrophomonas maltophilia (n=217), and Burkholderia cepacia (n=4) using the Clinical and Laboratory Standards Institute (CLSI) standard broth microdilution method. Iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB), prepared following the recently ...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
CONCLUSIONS: Our findings showed MALDI-TOF MS-based identification of NFGNB as a good, robust method for high-throughput laboratories. PMID: 28948958 [PubMed - in process]
Source: The Indian Journal of Medical Research - Category: Biomedical Science Authors: Tags: Indian J Med Res Source Type: research
Conclusions Incidence of DA-HAIs in the study intensive care unit was high compared with that of developed countries. Formulation and implementation of standard infection control protocols, active surveillance of DA-HAIs, and antimicrobial stewardship are urgently needed in our country.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
This report was aimed to draw attention to the accurate identification of P.luteola in clinical samples, upon the isolation and identification in two cases in the medical microbiology laboratory of a university hospital. In February 2011, a 66-year-old man, with chronic obstructive pulmonary disease, coronary artery disease and aplastic anemia, was admitted to our hospital due to progressive dyspnea. A chest tube was inserted on the 20th day of admission by the reason of recurrent pleural effusion. Staphylococcus aureus and a non-fermentative gram-negative bacillus (NFGNB) with wrinkled, sticky yellow colonies were isolate...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Abstract Universal stress proteins are ubiquitously expressed in bacteria, archaea and plants and other eukaryotes. A general property of USPs is their role in adaptation of bacteria to oxidative stress, high temperature, low pH and/or hypoxia. There is increasing evidence that these proteins facilitate the adaption of bacterial pathogens to the human host environment, thereby facilitating colonisation and pathogenicity. USPs in Mycobacterium tuberculosis are well studied and may play a role in latency of tuberculosis. USP expressed by Acinetobacter baumannii, Listeria monocytogenes and Salmonella enterica serovar...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Conclusion Genospecies among the A. baumannii complex had heterogeneous susceptibility profiles to aminoglycosides. Aminoglycosides, except gentamicin, remained good in vitro antimicrobial activity against P. aeruginosa. Further in vivo clinical data and continuous resistance monitoring are warranted for clinical practice guidance.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Conclusions These in vitro data highlight the therapeutic potential of the new LpxC inhibitor LPC-058 against MDR/XDR strains and set the stage for subsequent in vivo studies.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Authors: Tags: Original research Source Type: research
Clinical isolates of Acinetobacter baumannii complex (1312), Stenotrophomonas maltophilia (464), and Burkholderia cepacia species complex (30) were selected from medical centers in the United States (USA), Europe and the Mediterranean (EU-M) region, Latin America, and Asia Pacific. Only one isolate per infected patient episode was included and local identifications were confirmed by the monitoring laboratory. Susceptibility testing was performed at the monitoring laboratory using the reference broth microdilution method as described by Clinical and Laboratory Standards Institute (CLSI).
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research
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