Lab-grown Ovaries Prove Promising in Mice Lab-grown Ovaries Prove Promising in Mice
Artificial ovaries grown in a lab might someday be available for women with infertility due to cancer treatments or other conditions, a study in mice suggests.Reuters Health Information
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
This study evaluated the association between BRCA mutation status and serum anti-Müllerian hormone (AMH) level in young, reproductive-aged patients with breast cancer. Materials and Methods: Patients ≤ 40 years of age with breast cancer and who had known BRCA status and baseline serum AMH level at Samsung Medical Center, Seoul, Korea, were considered for inclusion. A total of 52 BRCA mutation carriers (27 BRCA1 and 25 BRCA2) and 264 non-carriers were selected for analyses. The serum level of AMH was compared according to presence of a BRCA mutation, and linear and logistic regression analyses were performed to eva...
It is predicted that by 2030 the number of new cancer cases per year will rise to 23.6 million. As the number of cancer patients rises, so does the number of survivors whose quality of life is impacted by infertility. While the use of follicular stimulating hormone (FSH) and luteinizing hormone (LH) has not proven to be harmful to female cancer patients, cancer treatment itself may be gonadotoxic. Therefore, patients facing a cancer diagnosis can preserve future fertility through embryo or oocyte cryopreservation.
Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy affecting reproductive aged women. However, it is often underdiagnosed. Given the long-term health risks associated with PCOS, such as infertility, diabetes, and endometrial cancer, it is important to optimize accurate diagnosis. A self-reported questionnaire that identifies women who should undergo clinical screening for PCOS could reduce the number of women who go undiagnosed and untreated and would also facilitate research on risk factors for this condition.
CONCLUSION: Based on identified interactome, it is plausible that HE4 plays a crucial role in fertilization, specifically in sperm maturation, motility and capacitation. PMID: 30919767 [PubMed - as supplied by publisher]
CONCLUSIONS: The EAOC patients were often diagnosed at a younger age, an earlier stage, and related to nulliparity and infertility. Patients with EAOC had a better prognosis than non-EAOC, early stage rather than association with endometriosis may be the driver of survival. PMID: 30913953 [PubMed - as supplied by publisher]
Conclusion The efficacy of fertility preservation procedures in females with TS is still unknown. Future studies with focus on efficacy, safety and long-term follow-up are desperately needed. PMID: 30888127 [PubMed - in process]
Overall risk higher for developing cancer; increased risks seen for uterine, ovarian, lung, thyroid cancers
ConclusionsWhile awaiting replication of this study in larger populations, these findings challenge the presumed dominant importance of genetic parenthood. This raises questions about whether donor gametes could be presented as a worthy alternative earlier in treatment trajectories and whether investments in novel treatments enabling genetic parenthood, like in vitro gametogenesis, are proportional to their future clinical impact.
Muffin tops, man boobs, and bagel bumps: These are among the varied and perverse ways that the hormonal distortions inflicted on unwitting humans who consume the seeds of grasses, i.e., grains, show themselves. In our modern world filled with thousands of processed foods, there are plenty of landmines for health. Gummy bears and gumdrops will rot teeth, for instance. Indulge in a handful of dried prunes and you’ll have to schedule a substantial portion of your day on the toilet due to bowel irritants. But only wheat and grains are associated with a wide swath of health problems that range from autoimmune disease to m...