Harvard researchers reveal ‘ JetValves ’ , nanofiber heart valves with potential to regenerate, grow

In this study, we used a combination of synthetic polymers and ECM proteins to fabricate biocompatible JetValves that are hemodynamically competent upon implantation and support cell migration and re-population in vitro. Importantly, we can make human-sized JetValves in minutes – much faster than possible for other regenerative prostheses,” JetValve team lead Kevin Parker of Harvard’s Wyss Institute said in a prepared release. Today, both groups said they formed a cross-institutional team looking to generate a functional heart valve replacement with regenerative, reparative and growth potentials. The teams will also work towards creating a GMP-grade version of their manufacturing process to enable larger-scale production. The heart valves can be manufactured in all desired shapes and sizes for both adult and pediatric patients, according to the development team, taking only seconds to minutes to produce. “In our previous studies, the cell-derived ECM-coated scaffolds could recruit cells from the receiving animal’s heart and support cell proliferation, matrix remodeling, tissue regeneration, and even animal growth. While these valves are safe and effective, their manufacturing remains complex and expensive as human cells must be cultured for a long time under heavily regulated conditions. The JetValve’s much faster manufacturing process can be a game-changer in this respect. If we can replicate these results in humans, this technology could hav...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiovascular Replacement Heart Valves Research & Development Harvard Wyss Institute Source Type: news