New lignan glycosides from the root barks of Litsea glutinosa

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Younan Wu, Yan Jin, Lin Dong, Yiying Li, Caiyun Zhang, Mei Gui, Xiaopo Zhang An investigation on the chemical constituents in the root barks of Litsea glutinosa was performed for the first time. Three new lignan glycosides named Litseasins A–C (1–3), together with a known one (4), were obtained. The structures of the new compounds were established through extensive spectroscopic analyses including HR-ESI–MS, NMR, and circluar dichroism (CD). The new compounds were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induce nitric oxide (NO) production in RAW264.7 murine macrophage cells. However, these compounds showed no inhibition on LPS-induced NO productions. Graphical abstract

Source: Phytochemistry Letters - May 18, 2017 Category: Chemistry Source Type: research