Unlocking the key to infertility in older women

Findings from new research may finally resolve, and potentially provide answers, as to why older women have higher incidences of miscarriage and have babies with chromosomal abnormalities.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Abstract A balanced Robertsonian translocation results from fusion of two acrocentric chromosomes. Carriers are phenotypically normal, and are often diagnosed because of recurrent miscarriages, infertility or aneuploid offspring. Mortality and site-specific cancer risks in carriers have not been prospectively investigated. We followed 1987 carriers diagnosed in Great Britain for deaths and cancer risk, over an average of 24.1 years. Standardised mortality (SMR) and incidence (SIR) ratios were calculated comparing the number of observed events against population rates. Overall mortality was raised for carriers diagnosed aged
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
CONCLUSIONS: Despite the significant proportion and recent growth of Catholic health care within the U.S. health care sector, little is known about reproductive health outcomes in these settings and in comparison with other settings. PMID: 30531578 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Asherman syndrome (AS) is a condition defined by the presence of intrauterine adhesions (IUAs) resulting when the bona fide endometrium is replaced by fibrotic tissues, causing the uterine walls to adhere to one another and causing symptoms such as infertility, recurrent miscarriage, menstrual abnormalities, pelvic pain, and abnormal placentation. A successful treatment for AS requires a comprehensive approach and prevention seems to be paramount and starts by optimizing the diagnostic strategy (1 –3).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
ConclusionFCM is widely used to assess cellular populations, but not typically employed for endometrial evaluation. FCM provides a rapid, detailed, and quantitative analysis and reduces inter-observer subjectivity bias. Detailed understanding of the normal endometrial immunophenotype, and associated deviations, may provide insight into the aetiology of infertile patients labelled “unexplained”. Failure despite transfer of high grade, or proven euploid blastocysts, is a difficult problem, and endometrial profiling may help identify research areas to determine potential future therapeutic interventions for this d...
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
AbstractThe aging-related decline in fertility is an increasingly pressing medical and economic issue in modern society where women are delaying family building. Increasingly sophisticated, costly, and often increasingly invasive, assisted reproductive clinical protocols and laboratory technologies (ART) have helped many older women achieve their reproductive goals. Current ART procedures have not been able to address the fundamental problem of oocyte aging, the increased rate of egg aneuploidy, and the decline of developmental potential of the eggs. Oocyte maturation, which is triggered by luteinizing hormone (LH) in vivo...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Background.Infertility is common after HCT predominantly as a result of the chemoradiotherapy used in conditioning. Patients are increasingly encouraged to store gametes, tissue or embryos before transplant for use after their potentially sterilising treatment. Furthermore, some patients do retain or recover fertility and conceive naturally.Methods:We sent questionnaires to 602 EBMT centers requesting retrospective details of number of pregnancies following either allogeneic or autologous HCT, use of artificial reproductive techniques (ART) and pregnancy outcome for all patients treated between 1995-2015.Results:47 centers...
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster I Source Type: research
Constitutional (germline) chromosomal rearrangements, including translocations and inversions, are well recognized for their potential to impact fertility and miscarriage risk [1,2]. Conventional chromosome studies are routinely performed on adult patients with histories of infertility or recurrent miscarriages, and it is under these circumstances when constitutional rearrangements are often revealed [1,2]. However, in this context, carriers of constitutional rearrangements are often phenotypically and cognitively normal (assuming the rearrangements are truly balanced and genes of clinical significance are intact) and thes...
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
The objective of this study is to assess a possible non-pharmacological solution to ovulatory dysfunction in these patients and perhaps improve other associated features of PCOS.Trial registrationClinicalTrials.gov, ID:NCT02630485. Registered on 15 December 2015.
Source: Trials - Category: Research Source Type: clinical trials
In an interview about her new memoir, "Becoming," the former first lady opened up about miscarriage and infertility
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
ConclusionPresence of adenomyosis seems to have adverse effects on IVF outcomes in clinical pregnancy rate, live birth rate and miscarriage rate. Screening for adenomyosis might be considered before ART so that the couple has better awareness of the prognosis.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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