Unlocking the key to infertility in older women

Findings from new research may finally resolve, and potentially provide answers, as to why older women have higher incidences of miscarriage and have babies with chromosomal abnormalities.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 24 April 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Giovanni Castellini, Lorenzo Lelli, Emanuele Cassioli, Valdo RiccaAbstractA growing body of evidences demonstrated that sexuality is an important topic in the clinical research of eating disorders (EDs), due to its association with specific psychopathological features, and etiological factors. The present review took into consideration the complex relationship between sexual behaviours, hormonal alterations and EDs psychopathology. Studies pertaining sexual behaviours in EDs were divided into those focusing on sexual dysf...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
For infertility patients, an IVF cycle can feel like a numbers game. How many follicles are developing well? How many oocytes are retrieved? How many will fertilize? And most important, how many embryos will be ready to transfer into the womb? Although many people say “it only takes one,” I have found that most people going through in vitro fertilization (IVF) are hoping for several. Why do people hope for several embryos? If it only takes one, why hope for more? For those struggling with infertility, safety in numbers may feel heartening. Some families hope to have more than one child, and welcome the chance t...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Fertility Infertility Men's Health Women's Health Source Type: blogs
Authors: Lopes LS, Esteves SC Abstract In recent years, growing evidence has challenged the notion that sperm quantity and quality are not essential for the success of assisted reproductive technology. DNA fragmentation assessments on ejaculated and testicular sperm harvested from non-azoospermic infertile men have reported a remarkable decrease in DNA damage in spermatozoa directly retrieved from the seminiferous tubules. Moreover, emerging evidence using molecular genetic techniques indicates that aneuploidy rates are lower in testicular sperm than in ejaculated counterparts. The use of testicular sperm from non-...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: At present, there is no high-quality evidence to support the routine use of hysteroscopy as a screening tool in the general population of subfertile women with a normal ultrasound or hysterosalpingogram in the basic fertility work-up for improving reproductive success rates.In women undergoing IVF, low-quality evidence, including all of the studies reporting these outcomes, suggests that performing a screening hysteroscopy before IVF may increase live birth and clinical pregnancy rates. However, pooled results from the only two trials with a low risk of bias did not show a benefit of screening hysteroscopy bef...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Abstract OBJECTIVE: To estimate the differences in frequency of septate uterus diagnosis and the association with infertility and previous miscarriage using three different criteria. METHODS: Secondary data-driven analysis of data from prospective study was performed based on data-set of 261 consecutive women of reproductive age from daily clinical practice in private clinic focused on diagnosis and treatment of congenital uterine malformations. Re-analysis of datasets was performed using following definitions of septate uterus: ASRM-2016, ESHRE/ESGE-2016, and CUME-2018 (Congenital Uterine Malformation by Exp...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Jie Cai1†, Yi Zhang1†, Yuying Wang1, Shengxian Li1, Lihua Wang1, Jun Zheng1, Yihong Jiang1, Ying Dong1, Huan Zhou1, Yaomin Hu1, Jing Ma1, Wei Liu1,2*† and Tao Tao1*† 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China 2Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China Background: Infertility and dyslipidemia are frequently present in both women...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Eleni Angelopoulou1,2, Clarisse Quignon1, Lance J. Kriegsfeld3 and Valérie Simonneaux1* 1Institut des Neurosciences Cellulaires et Intégratives (CNRS UPR 3212), Université de Strasbourg, Strasbourg, France 2Netherlands Institute for Neuroscience (NIN), Amsterdam, Netherlands 3Department of Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States Adaptation of reproductive activity to environmental changes is essential for breeding success and offspring survival. In mammals, the reproductive system displays regular cycles of activation a...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Di Che1†, Yanfang Yang2†, Yufen Xu1†, Zhenzhen Fang3, Lei Pi1, LanYan Fu1, Huazhong Zhou1, Yaqian Tan1, Zhaoliang Lu1, Li Li4, Qihua Liang5, Qingshan Xuan4* and Xiaoqiong Gu1,5,6* 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China 2Department of Prenatal Diagnosis, Maoming People’s Hospital, Maoming, China 3Program of Molecular Medicine, Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract Balanced reciprocal translocation carriers are usually phenotypically normal but are at an increased risk of infertility, recurrent miscarriage or having affected children. Preimplantation genetic testing on chromosomal structural rearrangement (PGT-SR) offers a way to screen against unbalanced embryos. Here, we demonstrated a new method to distinguish carrier from noncarrier embryos. Translocation breakpoints were first delineated by nanopore sequencing followed by polymerase chain reaction (PCR) across breakpoints. High-resolution breakpoint mapping was successful in all (9/9) balanced reciprocal transl...
Source: Genomics - Category: Genetics & Stem Cells Authors: Tags: Genomics Source Type: research
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