Discovery may help unlock infertility in older women

Australian researchers may have found the key to unlocking the mystery of infertility, miscarriage and birth defects in older women over the age of 37.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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ConclusionIn light of connecting etiological link between infertility and RM as reviewed in this study, interrogating the oocyte-specific genes with suspected roles in reproductive biology, in cases of unexplained RM, may open new possibilities in widening our understanding of RM pathophysiology.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ni ME Abstract Context: There is increasing evidence for MIS/AMH physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy. Objective: To investigate the association of MIS/AMH levels with risk of adverse obstetric outcomes. Design: Retrospective cohort study. Setting: Academic fertility center. Patients: Women who became pregnant through in vitro fertilization (IVF) between January 2012-October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestation, miscarriage before 20 weeks, medically indicated preterm deliverie...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
The thyroid is critical in metabolism, steroidogenesis and development. While treatment of thyroid abnormalities in reproductive-aged women is universally accepted, the threshold for thyroid stimulating hormone (TSH) is still debated. The American Society for Reproductive Medicine suggests 2.5 mIU/L while the American Thyroid Association recommends 4.12 mIU/L. Fertility, particularly ovulation, implantation and miscarriage risk, is impaired by thyroid dysfunction, but there is limited understanding of artificial reproductive technologies (ART) outcomes in euthyroid women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Increased serum C-reactive protein (CRP) levels have recently been reported to reduce fecundity in healthy eumenorrheic women with a history of 1-2 pregnancy losses. 1 As subclinical systemic inflammation may impede maternal immune tolerance, implantation and embryonic development might be compromised. Inflammation could, thus, also serve as a causative factor for the substantial proportion of miscarriages that reveal normal karyotypes after analysis of products of conception (POCs). To evaluate in infertile women the relationship between pre-pregnancy CRP levels and POC karyotype was the objective of this study.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Ovulation Induction with IUI is a common first step in the treatment of infertility given its lower cost and ease of implementation compared to IVF. Disadvantages include lower pregnancy rates and thus longer time to conception. PGT-A provides the advantage of lower miscarriage rates (SAB). We sought to compare the pregnancy outcomes and cost per cycle of IUI and IVF/ PGT-A.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
YK Sharma, Shivanti ChauhanIndian Journal of Dermatology 2018 63(5):418-423 Rowell's syndrome (RS) is recognized since 1963 as a presentation of lupus erythematosus (LE) with erythema multiforme-like lesions and characteristic immunological changes. Antiphospholipid syndrome (APS) encompasses antibodies to phospholipids/phospholipid-binding cofactor proteins and/or circulating lupus anticoagulant with clinical manifestations of thrombosis such as recurrent spontaneous abortions, etc. A 32-year-old female with primary infertility since marriage (7 years) and sequential appearance, for the past 6 months, of various lupu...
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Abstract OBJECTIVE: To ascertain whether stress biomarker and psychological indices of stress may predict both conception and miscarriage rates in women undergoing in-vitro fertilization/ intracytoplasmic sperm injection (IVF/ ICSI). DESIGN: Prospective observational study. SETTING: A university-affiliated tertiary hospital. POPULATION OR SAMPLE: Infertility women who were undergoing fresh or frozen IVF/ICSI cycles. METHODS: Subjects were recruited to (1) completed validated psychological questionnaires (visual analogue scale of stress, state trait anxiety inventory, perceived stress scale, fer...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Abstract Infertile male with small supernumerary marker chromosomes (sSMCs) were studied. Overall, 37 own patients and 166 cases from the literature were included. sSMCs of our own cases were characterized by multicolor-FISH probe sets. Available clinical data of the infertile males were also evaluated, and meta-analysis on suitability of molecular karyotyping for sSMC characterization was done. As a result, sSMCs can be optimally characterized by single-cell directed (molecular) cytogenetics. In infertile males, sSMCs derive predominantly from one of the acrocentric chromosomes, mainly chromosomes 15, 14, and 22....
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - Category: Genetics & Stem Cells Authors: Tags: Sex Dev Source Type: research
Infertile male with small supernumerary marker chromosomes (sSMCs) were studied. Overall, 37 own patients and 166 cases from the literature were included. sSMCs of our own cases were characterized by multicolor-FISH probe sets. Available clinical data of the infertile males were also evaluated, and meta-analysis on suitability of molecular karyotyping for sSMC characterization was done. As a result, sSMCs can be optimally characterized by single-cell directed (molecular) cytogenetics. In infertile males, sSMCs derive predominantly from one of the acrocentric chromosomes, mainly chromosomes 15, 14, and 22. Interestingly, al...
Source: Sexual Development - Category: Biology Source Type: research
Abstract BACKGROUND: Pregnancies following assisted reproductive technology (ART) may have elevated potential risk of pregnancy loss (PL) when compared to natural conception. However, rare studies comprehensively analyzed the IVF/ICSI cycle-dependent factors for loss of clinical pregnancy. Therefore, we aimed to determine the ART subgroup-specific risks of PL throughout pregnancy and explore different risk factors for early miscarriage and late miscarriage among pregnancies conceived through ART. METHODS: A retrospective cohort study was launched in two infertility treatment centers in Nanjing and Changzhou i...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
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