First validation of the gout activity score against gout impact scale in a primary care based gout cohort

Conclusion This first study to validate GAS against the GIS found moderate correlation. However, this study did not examine the predictive validity of GAS, and prospective studies are needed before GAS can be used widely.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Lee Yung-Po Liaw The effects of genetic variants on the interaction between hyperlipidemia and sex have not been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National Health Insurance Research Database (NHIRD), we examined hyperlipidemia, sex, and their relationship with gout among Taiwanese adults with the human leukocyte antigen B (HLA-B) genetic variants. Hyperlipidemia was present in 1437 patients with gout. Sex and hyperlipidemia had significant associations on gout risk, with hyperlipidemia showing a relatively stronger effect. Gout was present in men, with an odds ratio (OR) of 1.9...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Publication date: Available online 22 March 2019Source: Joint Bone SpineAuthor(s): Qunchuan Zong, Yibo Hu, Qifu Zhang, Xiuxiu Zhang, Jingwen Huang, Tao WangAbstractObjective:A systematic review and meta-analysis were conducted to investigate the associations of hyperuricemia, gout, and uric acid (UA)-lowering therapy with the risk of fractures.Methods:Electronic searches on PubMed, the Cochrane Library, and Embase were conducted from inception to January 2, 2019. Observational studies assessing the effects of hyperuricemia, gout, and UA-lowering therapy on fractures were included in the meta-analysis. Summary risk estimate...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Dyve Bioscience this week touted data from a human proof-of-concept pilot study of its transdermal sodium bicarbonate therapy for pain reduction in people with acute gout flare. The study enrolled 24 people with a history of gout. Those in the active treatment group were given lotion containing sodium bicarbonate and menthol, while those in the placebo group were given lotion without sodium bicarbonate or menthol. Investigators told the participants to report to the clinic within 36 hours of flare onset. Get the full story at our sister site, Drug Delivery Business News. The post Dyve Bioscience touts proof-of-concept stud...
Source: Mass Device - Category: Medical Devices Authors: Tags: Pain Management Pharmaceuticals dyvebioscience Source Type: news
AbstractPrevious epidemiological investigations have evaluated the association between gout, serum uric acid levels, and obstructive sleep apnea syndrome (OSAS), but with inconsistent results. We conducted this meta-analysis aiming at providing clear evidence about whether OSAS patients have higher serum uric acid levels and more susceptible to gout. Relevant studies were identified via electronic databases from inception to December 17, 2018. Study selection was conducted according to predesigned eligibility criteria, and two authors independently extracted data from included studies. The hazard ratio (HR) and weighted me...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
PMID: 30882192 [PubMed - in process]
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout ...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
ConclusionThere was no significant association between the patterns of electronic devices use and CTS symptoms. The high prevalence of CTS symptoms necessitates awareness programs, especially among the young population. Although this work did not prove the association, further studies with confirmatory clinical testing are recommended.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
CHICAGO—The Gout and Hyperuricemia scientific session at the 2018 ACR/ARHP Annual Meeting opened with a talk by Tony R. Merriman, PhD, a research professor at the University of Otago, New Zealand. His talk focused on molecular epidemiology, with an emphasis on the interactions between genes and environmental exposures, and their contributions to gout. Dr. Merriman... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Crystal Arthritis Meeting Reports 2018 ACR/ARHP Annual Meeting Gout Human Functional Genomics Projects hyperuricemia Source Type: research
Publication date: Available online 17 March 2019Source: Chemico-Biological InteractionsAuthor(s): Georgios Pantouris, Evangelos Dioletis, Ying Chen, David C. Thompson, Vasilis Vasiliou, Elias J. LolisAbstractALDH16 is a novel family of the aldehyde dehydrogenase (ALDH) superfamily with unique structural characteristics that distinguish it from the other ALDH superfamily members. In addition to structural characteristics, there is an evolutionary-related grouping within the ALDH 16 genes. The ALDH16 isozymes in frog, lower animals, and bacteria possess a critical Cys302 residue in their active site, which is absent from ALD...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
AbstractIn suspected and diagnosed rheumatoid arthritis (RA), magnetic resonance imaging (MRI) allows detection of all relevant pathologies, such as synovitis, tenosynovitis, bone marrow edema (osteitis), bone erosion and cartilage damage. MRI is more sensitive than clinical examination for monitoring disease activity (i.e., inflammation) and more sensitive than conventional radiography and ultrasonography for monitoring joint destruction. In suspected RA, MRI bone marrow edema predicts development of RA, and in early RA patients, it predicts subsequent structural damage progression. CT is the standard reference imaging mo...
Source: La Radiologia Medica - Category: Radiology Source Type: research
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