Low penetration of caspofungin into cerebrospinal fluid following intravenous administration of standard doses

• Caspofungin (CAS) shows low capacity to penetrate into the human central nervous system (CNS).• In inflamed meninges, penetration of CAS may be increased in some patients.• Standard doses of CAS are not sufficient to treat fungal CNS infections.

Source: International Journal of Antimicrobial Agents - May 17, 2017 Category: Drugs & Pharmacology Authors: Volker Strenger, Fedja Farowski, Carsten M üller, Nora Hofer, Hans Jürgen Dornbusch, Daniela Sperl, Herwig Lackner, Martin Benesch, Christian Urban Tags: Short Communication Source Type: research