Complement in ANCA-associated vasculitis: mechanisms and implications for management

Nature Reviews Nephrology 13, 359 (2017). doi:10.1038/nrneph.2017.37 Authors: Min Chen, David R. W. Jayne & Ming-Hui Zhao Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of potentially life-threatening autoimmune diseases. The main histological feature in the kidneys of patients with AAV is pauci-immune necrotizing crescentic glomerulonephritis with little immunoglobulin and complement deposition in the glomerular capillary walls. The complement system was
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Review Source Type: research