Disease Stage-Dependent Changes in Cardiac Contractile Performance and Oxygen Utilization Underlie Reduced Myocardial Efficiency in Human Inherited Hypertrophic Cardiomyopathy [Cardiomyopathies]

Conclusions— Different mechanisms underlie reduced MEE at the early and advanced stage of hypertrophic cardiomyopathy. The initial increase and subsequent reduction in myocardial oxygen consumption during disease progression indicates that energy deficiency is a primary mutation-related event, whereas mechanisms secondary to disease remodeling underlie low MEE in HOCM. Our data highlight that the benefit of therapies to improve energetic status of the heart may vary depending on the disease stage and that treatment should be initiated before cardiac remodeling.

http://circimaging.ahajournals.org/cgi/content/short/10/5/e005604?rss=1

Source: Circulation: Cardiovascular Imaging - May 5, 2017 Category: Radiology Authors: Guclu, A., Knaapen, P., Harms, H. J., Parbhudayal, R. Y., Michels, M., Lammertsma, A. A., van Rossum, A. C., Germans, T., van der Velden, J. Tags: Cardiomyopathy, Heart Failure, Hypertrophy, Remodeling, Valvular Heart Disease Cardiomyopathies Source Type: research