Every member of the kingdom Animalia is a potential vector of human pathogens
Publication date: August 2017 Source:Microbial Pathogenesis, Volume 109 Author(s): Seema Patel Zoonotic diseases are a subset of infectious diseases, which account for enormous morbidity and mortality. Pathologies like malaria, rabies, Lyme disease, leptospirosis, avian flu etc. are microbe- and parasite-caused ailments, where the etiological agents are introduced into or on the human body via ticks, mosquitoes, birds, rodents, bats, and deer, among other members of kingdom Animalia. While some of the zoonotic diseases are well-investigated and caution taken against, a lot many are yet to be recognized. This ignorance costs health, and lives, especially in developing countries. To promote awareness regarding the risks of immunogenicity and pathogen dissemination by hitherto unknown non-plant organisms, the members of kingdom Animalia, this letter has been compiled. The vector exploitation mechanisms of the pathogens, and in silico evidences of conserved protein domains across the potential pathogen reservoirs have been mentioned to underline the importance of this topic.
Fatima Concei ção-Silva, Jessica Leite-Silva, Fernanda N. Morgado
(Imperial College London) Using two experimental anti-malarial vaccines, which work in different ways, can greatly reduce the number of malaria infections in animal studies.
Anti-malarial pre-erythrocytic vaccines (PEV) target transmission by inhibiting human infection but are currently partially protective. It has been posited, but never demonstrated, that co-administering transmission-blocking vaccines (TBV) would enhance malaria control. We hypothesized a mechanism that TBV could reduce parasite density in the mosquito salivary glands, thereby enhancing PEV efficacy. This was tested using a multigenerational population assay, passagingPlasmodium berghei toAnopheles stephensi mosquitoes. A combined efficacy of 90.8% (86.7 –94.2%) was observed in the PEV +TBV antibody group, higher than...
In conclusion, we have identified an analog of curcumin for potential applications against leishmaniasis, based on its strong antiparasitic activity and low toxicity. This curcumin analog compares favorably, at least in vitro, with the existing medication miltefosine. Graphical abstract
Publication date: Available online 18 June 2018 Source:Parasitology International Author(s): Zhenzhen Wang, Miho Shibata, Yen Thi Hoang Nguyen, Yayoi Hayata, Nariaki Nonaka, Haruhiko Maruyama, Ayako Yoshida Ascarid Larva Migrans Syndrome (ascarid LMS) is a clinical syndrome in humans, caused by the migration of animal roundworm larvae such as Toxocara canis, Toxocara cati and Ascaris suum. Humans may acquire infection by ingesting embryonated eggs, or infective larvae of these parasites in contaminated meat and organ meats. To detect these pathogenic contaminations, a novel nested multiplex PCR system was developed. Our n...
In conclusion, our results suggest that line differences in productive performance do not influence host responses to coccidiosis when offered nutrient adequate diets. Graphical abstract
Publication date: Available online 18 June 2018 Source:Ticks and Tick-borne Diseases Author(s): Ana Paula S. Feitosa, Marlos M. Chaves, Dyana L. Veras, Dayse M. Vasconcelos de Deus, Nairomberg C. Portela, Alberon R. Araújo, Luiz C. Alves, Fábio A. Brayner The aim of this study was to evaluate aspects of the innate cellular and humoral immune response by evaluating hemocyte dynamics, phagocytosis, phenoloxidase (PO) activity and nitric oxide (NO) production in Rhipicephalus sanguineus sensu lato (s.l.) (Acari: Ixodidae) infected with Leishmania infantum and to assess the persistence of parasites at time 0 and...
Dear readers, I will soon be posting my 500th Case. Hooray!! To celebrate, I would like to recognize the creativity of my readers by displaying a photograph of your parasite-related artwork on my blog. I will then put the names of all of the individuals who submitted a photo of their art in a hat and pick 3 names to receive a special parasite prize ☺ If you would like to send me a photo that I can post on my blog on July 2nd, please send it to firstname.lastname@example.orgNow for this week's case - some beautiful eggs from my lab (images and video by Heather Rose):Identification?
For 30 years, scientists have fought to eliminate a horrifying parasite. Suddenly, it has begun infecting dogs in Chad, threatening to undo decades of progress.
Dr. Ernesto Ruiz-Tiben has saved tens of millions of people from painful parasitic infections.