Organic-inorganic hybrid nanoparticles controlled delivery system for anticancer drugs
In this study, iron oxide nanoparticles were prepared then surface modified via diazonium chemistry and coated with chitosan, and its derivative chitosan-grafted polylactic acid. The purpose was to increase the stability of the nanoparticles in physiological solution, heighten drug-loading capacity, prolong the release, reduce the initial burst effect and improve in vitro cytotoxicity of the model drug doxorubicin. The materials were characterized by DLS, ζ-potential, SEM, TGA, magnetization curves and release kinetics studies. Results confirmed the spherical shape, the presence of the coat and the advantages of using chitosan, particularly its amphiphilic derivative, as a coating agent, thereby surpassing the qualities of simple iron oxide nanoparticles. The coated nanoparticles exhibited great stability and high encapsulation efficiency for doxorubicin, at over 500μg per mg of carrier. Moreover, the intensity of the initial burst was clearly diminished after coating, hence represents an advantage of using the hybrid system over simple iron oxide nanoparticles. Cytotoxicity studies demonstrate the increase in cytotoxicity of doxorubicin when loaded in nanoparticles, indirectly proving the role played by the carrier and its surface properties in cell uptake. Graphical abstract
PMID: 29227217 [PubMed - in process]
CONCLUSIONS: The greater frequency of FOP nutrition references on heavily processed foods raises questions about the extent to which discretionary FOP labelling supports public health efforts to promote healthy eating. PMID: 29227216 [PubMed - in process]
Intersect ENT Inc. won Food and Drug Administration approval for a sinus implant that delivers an anti-inflammatory steroid to treat nasal polyps. It isn't the Menlo Park company's (NASDAQ: XENT) first product to be greenlighted by regulators — Intersect's previous three products were medical devices — but it is the first to be approved as a drug. Sinuva is placed within a sinus implant, which is put in during a routine visit to a docto r's office. It expands into the sinus cavity and delivers…
Patients with oral clefts have an increased risk of other malformations, syndromes, and lower academic performance in school. Few studies have investigated if laterality of clefts is associated with medical and academic outcomes. Oral clefts have nonrandom laterality, with left‐sided clefts occurring approximately twice as often as right‐sided clefts. Using a retrospective study design, we examined potential associations of cleft attributes and outcomes in patients with cleft lip with or without cleft palate (CL/P) born in 2003–2010 who were treated at the Seattle Children's Craniofacial Center. The following var...
Most differences from expectant management were seen at 39 and 40, but not 41, weeks of gestation.Medscape Medical News
Conclusion: There are variations in vaccination practice across Europe. Children with CKD, those undergoing dialysis, and transplant candidates should receive age-appropriate vaccinations before RTx as well as before the transition to adult nephrology clinics and antibody levels should be monitored to evaluate the immunization status before and after RTx.Nephron
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Clinicians should be aware that offspring of moms with RA may have higher risk for RA, thyroid disease, or epilepsy, researchers warn.Medscape Medical News
U.S. Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response. 12/12/2017 This 34-page document from TRACIE (Technical Resources, Assistance Center, and Information Exchange) combines excerpts from the Emergency Preparedness Final Rule and the recently released Interpretive Guidelines from the Centers for Medicare and Medicaid Services (CMS) to provide a consolidated overview document for the Ambulatory Surgical Center (ASC) Requirements. It provides the requirements for the Emergency Plan; Policies and Procedures; Communications Plan; Training and Testing; and Integrated Hea...
U.S. Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response. 12/12/2017 This 38-page document from TRACIE (Technical Resources, Assistance Center, and Information Exchange) combines excerpts from the Emergency Preparedness Final Rule and the recently released Interpretive Guidelines from the Centers for Medicare and Medicaid Services (CMS) to provide a consolidated overview document for the Clinics, Rehabilitation Agencies, and Public Health Agencies as providers of Outpatient Physical Therapy and Speech-Language Pathology Services Requirements. (PDF)