Effective and Safe Mannitol Administration in Patients Undergoing Supratentorial Tumor Surgery: A Prospective, Randomized and Double Blind Study

The management of increased intracranial pressure (ICP) and brain relaxation are the main factors determining the clinical and surgical outcomes in neurosurgery [1]. Although the safe and effective dose of mannitol, the duration of administration and its use in combination with loop diuretics, such as furosemide, are still matters of debate, mannitol remains a common treatment approach for brain relaxation [2]. Distal loop diuretics promote further fluid excretion and sustain the osmotic effect initiated by mannitol.

Source: Clinical Neurology and Neurosurgery - May 15, 2017 Category: Neurosurgery Authors: Eren Akcil, Ozlem Korkmaz Dilmen, Esra Sultan Karabulut, Serdar Selcuk Koksal, Fatis Altindas, Yusuf Tunali Source Type: research