Diabetes drug may help symptoms of autism-associated condition
Metformin, the most widely used drug to treat type 2 diabetes, could potentially be used to treat symptoms of Fragile X syndrome, an inherited form of intellectual disability and a cause of some forms of autism.
Publication date: 15 April 2019Source: Sensors and Actuators B: Chemical, Volume 285Author(s): Yu-Wen Chen, Arun Prakash Periasamy, Chien-Fu Chen, Huan-Tsung ChangAbstractThe monitoring of glucose levels in blood is extremely important for the effective control of diabetes. Nanomaterial-based approaches for the quantification of glucose typically require two steps: material preparation and the actual glucose measurement. Herein, we report a single-step method that combines these functions via the in situ growth of Cu2O/Ag nanoparticles (NPs). Mechanistically, we use glucose itself to reduce Cu2+ and Ag+ ions that are stabi...
DIABETES type 2 symptoms include unexplained weight loss, passing more urine than normal, and feeling very tired. But you could also be at risk of high blood sugar if you have this painful sign hanging from your skin.
An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial a nd detrimental effects on glomeruli function.
Gain-of-function mutations in TRPC6 cause familial focal segmental glomerulosclerosis, and TRPC6 is upregulated in glomerular diseases including diabetic kidney disease. We studied the effect of systemic TRPC6 knockout in the Akita model of type 1 diabetes. Knockout of TRPC6 inhibited albuminuria in Akita mice at 12 and 16 weeks of age, but this difference disappeared by 20 weeks. Knockout of TRPC6 also reduced tubular injury in Akita mice; however, mesangial expansion was significantly increased.
A 52-year-old man with diabetes mellitus, congestive heart failure, morbid obesity (body mass index: 37), and chronic kidney disease started peritoneal dialysis using a surgically inserted catheter (midline incision). Catheter dysfunction necessitated surgical repositioning. During the operation, a cavity localized in the subcutaneous fat of the abdominal wall was discovered, with connection to the peritoneum space and the entire catheter within the cavity. The malfunctioning catheter was replaced through the same insertion site without an attempt to fix the cavity.
Accessing the criminal justice system is a basic human right protected internationally by the Convention on Rights of Persons with Disabilities (CRPD). However, one group within the broader disability sphere who finds accessing the criminal justice system ...
This article presents some of the challenges and inequities faced by African-American families that impact their quality of life using critical race theory (CRT). Also, it reviews results obtained by a study of 123 African-American families raising children with disabilities. The article offers implications for policy and practice and discusses the role for social workers in addressing disparities in healthcare and other areas. PMID: 30646824 [PubMed - as supplied by publisher]
Sugar could become an effective replacement for metal in contrast agents in magnetic resonance tomography analyses, according to researchers from John Hopkins University and Lund University in Sweden.There has been heated debate over the safety of certain contrast agents, and the Food and Drug Administration has warnedthat gadolinium-based contrast agents (GBCAs) can linger in the brain for months or years after the patient ’s procedure. Using alternatives like sugar could potentially diminish the risk of adverse side effects associated with GBCAs. Studies using animals demonstrated that D-glucose could be a po...
NHS England has been urged to dramatically increase its funding for reviews of learning disability deaths, as clinical commissioning groups have revealed large backlogs with their investigations
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