Diabetes drug may help symptoms of autism-associated condition

Metformin, the most widely used drug to treat type 2 diabetes, could potentially be used to treat symptoms of Fragile X syndrome, an inherited form of intellectual disability and a cause of some forms of autism.
Source: ScienceDaily Headlines - Category: Science Source Type: news

Related Links:

TYPE 2 diabetes can be controlled by eating the right kind of diet and cutting down on foods that are high in sugar, fat and salt. If you have diabetes but love cheese, try replacing your regular choice with this type to keep the condition under control.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion: These newly identified key genes and pathways in mice might provide valuable information regarding the pathogenesis of GDM and might be used to improve early diagnosis, prevention, drug design, and clinical treatment.Cell Physiol Biochem 2018;50:2260 –2271
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Rodrigo S. Delevatti, Ana Carolina Kanitz, Cristine L. Alberton, Elisa Corr êa Marson, Patricia Dias Pantoja, Carolina DertzbocherFeil Pinho, Salime Chedid Lisboa, Luiz Fernando M. Kruel
Source: Frontiers in Physiology - Category: Physiology Source Type: research
People with diabetes mellitus are at higher risk of developing serious ascending infections of the urinary tract. The traditional explanation has focused on the role of glycosuria in promoting bacterial growth. Using mouse models, Murtha et al. demonstrate that when the intracellular insulin signaling pathway is compromised, antimicrobial defenses are compromised too, and the mice are unable to effectively handle uropathogenic E. coli introduced experimentally into the urinary tract. These observations strongly support the hypothesis that the antimicrobial defenses of the kidney are dependent on insulin, and the urinary tr...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We report that type 2 diabetic mice have increased UTI risk. Moreover, insulin-resistant prediabetic mice have increased UTI susceptibility, independent of hyperglycemia or glucosuria. To identify how insulin resistance affects renal antimicrobial defenses, we genetically deleted the insulin receptor in the kidney’s collecting tubules and intercalated cells. Intercalated cells, located within collecting tubules, contribute to epithelial defenses by acidifying the urine and secreting antimicrobial peptides (AMPs) into the urinary stream. Collecting duct and intercalated cell–specific insulin receptor deletion di...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Allowing insurance companies to exclude preexisting conditions from health insurance coverage could cost consumers with illnesses like asthma, arthritis, cancer, diabetes, and high blood pressure thousands of dollars in increased out-of-pocket costs, according to a Commonwealth Fund report by Sherry Glied and Adlan Jackson of New York University. In a related post, the Commonwealth Fund's Sara Collins explains that some Republican proposals, such as the Ensuring Coverage for Patients with Pre-Existing Conditions Act, would erode ACA protections. Even thought the bill would prevent insurers from refusing to sell a plan to ...
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Source Type: research
TYPE 2 diabetes is a lifelong condition, but improving your diet and losing excess weight can help control blood glucose and prevent complications from occurring. According to one nutritionist, there is one particular type of weight loss diet that can diminish the effects of diabetes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Americans should sit less and move more, even if that activity comes in tiny chunks, according to the U.S. Department of Health and Human Services’ (HHS) latest physical activity guidelines. The core recommendations in the 2018 Physical Activity Guidelines for Americans, which were published Monday in the Journal of the American Medical Association, aren’t all that different from the previous iteration, which was released in 2008. The tone, however, has shifted to include more manageable forms of activity and to promote benefits of exercise that go beyond physical health, such as improved cognitive function, me...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Exercise/Fitness onetime overnight Source Type: news
LITTLE ROCK, Ark. - A disability insurer must reconsider a long-term disability (LTD) claim after reviewing the claimant's Social Security disability benefits records because the insurer represented to the claimant that the Social Security records would be considered as part of the review of the claimant's appeal, an Arkansas federal judge said Oct. 18 in remanding the claim to the administrator (Michael Buquoi v. United States Life Insurance Co., No. 18-093, E.D. Ark., 2018 U.S. Dist. LEXIS 179172).
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - Category: Medical Law Source Type: news
PHOENIX - A disability claimant's bad faith claim and request for punitive damages can proceed because the claimant presented an issue of fact as to whether the insurer's termination of disability benefits was reasonable, an Arizona federal judge said Nov. 1 in denying the insurer's motion for summary judgement (Kelly Ann Tyler v. United States Life Insurance Co., et al., No. 16-939, D. Ariz., 2018 U.S. Dist. LEXIS 187001).
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - Category: Medical Law Source Type: news
More News: Autism | Diabetes | Diabetes Type 2 | Disability | Endocrinology | Fortamet | Fragile X Syndrome | Metformin