Skin cancer on the rise

New diagnoses for two types of skin cancer increased in recent years, according to a team of researchers. Their paper uses medical records from the Rochester Epidemiology Project to compare diagnoses of basal cell carcinoma and squamous cell carcinoma ? both nonmelanoma skin cancers ? between 2000 and 2010 to diagnoses in prior years.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSIONS: Our large study suggests that prevention of melanoma in NMSC patients is mandatory, especially for patients which develop a NMSC under 40 years of age. PMID: 31042854 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Conclusions: Our results underestimate the direct costs of nmsc because inpatient services and non-physician costs were not included in the calculations. The present research represents a first step in understanding the cost burden of nmsc in Saskatchewan. PMID: 31043813 [PubMed - in process]
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
The authors discuss the potential use and limitations of immunotherapy among patients with squamous cell cancer, basal cell carcinoma, and other skin cancers.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Nonmelanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancers in the United States, with over 5.4 million cases diagnosed annually. Current therapeutic strategies and preventative measures have not been able to effectively manage this neoplasm. Therefore, better understanding of NMSC biology may provide novel mechanisms and targets for management of these cancers. Polo-like kinase 4 (PLK4) is a serine/threonine kinase, known to play a role in cell division by regulating centriole duplication.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Translational Studies Source Type: research
CONCLUSION: Our findings confirm that superficial radiotherapy is an effective treatment for early BCC or SCC of the vermilion lip, especially in the ageing population, in high-risk tumours, and even if poor cosmetic outcome is expected from surgical excision. PMID: 30973789 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Zheng Y, Yang Y, Wang J, Liang Y Abstract Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) have exhibited a marked increase in incidence in previous decades and are the most common malignancies in Caucasian populations. Src homology 3 and multiple ankyrin repeat domains protein-associated RH domain-interacting protein (SHARPIN) has been identified as a commonly overexpressed proto-oncogene in several types of visceral cancer. However, to the best of our knowledge, the functions of SHARPIN in nonmelanoma skin cancer (NMSC) have not been described. The present study aimed to investigate the expre...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
DISCUSSION: The yearly number of patients with BCC or SCC treated with radiotherapy, does not reflect the increasing incidence of these tumours. Radiotherapy has potential good treatment outcome in terms of local control and toxicity and seem to be predominantly chosen for tumours located in the head-and-neck area. PMID: 30892970 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
CONCLUSIONS: Most NMSCs arising in sites of prior RT were of low-risk subtypes. Recurrence was similar to that observed in the general population. Current guidelines recommend surgical intervention for tumors arising in sites of prior RT because they are considered to be at high risk for recurrence. These findings suggest that an expanded role for less aggressive therapy may be appropriate, but further research is needed. PMID: 30865918 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Skin cancer can be broadly categorized into melanoma and nonmelanoma skin cancer (NMSC). Squamous cell carcinoma and basal cell carcinoma are the most common subtypes of NMSC. When a patient presents with a skin finding suspect for NMSC, a confirming skin biopsy is performed. On the basis of the biopsy results, patient factors, and clinical characteristics of the cancer, an appropriate form of treatment is selected. Mohs micrographic surgery (or Mohs) is a tissue-sparing surgical approach, utilizing frozen section margin control. Once removal of the NMSC has been assured by Mohs surgery, the resultant skin defect is evalua...
Source: JDNA: Journal of the Dermatology Nurses Association - Category: Dermatology Tags: FEATURE ARTICLES Source Type: research
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