Namibia: Prostate Cancer High Among Aawambo Men

[New Era] Windhoek -In Namibia, Aawambo men are at high risk of developing prostate cancer, according to the Cancer Association of Namibia (CAN).
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Publication date: Available online 2 June 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Tinghui Yin, Kun Wang, Chen Qiu, Xinling Zhang, Huichao Zhou, Yujia You, Jie Ren, Ren Mao, Biying Yang, Xiaoyan Miao, Jie Tian, Rongqin Zheng
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
This study presented a preliminary evaluation of 211At-labeled BBN derivative. Several nonradioactive iodine-introduced BBN derivatives (IB-BBNs) with different linkers were synthesized and their binding affinities measured. Because IB-3 exhibited a comparable affinity to native BBN, [211At]AB-3 was synthesized and the radiochemical yields of [211At]AB-3 was 28.2 ± 2.4%, with a radiochemical purity of>90%. The stability studies and cell internalization/externalization experiments were performed. [211At]AB-3 was taken up by cells and internalized; however, radioactivity effluxed from cells over time....
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
Authors: Miranti CK, Moore S, Kim Y, Chappeta VR, Wu K, De B, Gokhale V, Hurley LH, Reyes-Reyes EM Abstract The androgen receptor (AR) is a major driver of prostate cancer development and progression. Men who develop advanced prostate cancer often have long-term cancer control when treated with androgen-deprivation therapies (ADT). Still, their disease inevitably becomes resistant to ADT and progresses to castration-resistant prostate cancer (CRPC). ADT involves potent competitive AR antagonists and androgen synthesis inhibitors. Resistance to these types of treatments emerges, primarily through the maintenance of ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionThese findings confirmed the complementary information provided by GC –MS and1H NMR, enabling a more comprehensive picture of the altered metabolites, underlying pathways and deepening the understanding of PCa development and progression.
Source: Metabolomics - Category: Biology Source Type: research
Bone is one of the preferential sites of distant metastases from malignant tumors, with the highest prevalence observed in breast and prostate cancers. Patients with bone metastases (BMs) may experience skeletal-related events, such as severe bone pain, pathological fractures, spinal cord compression, and hypercalcemia, with negative effects on the quality of life. In the last decades, a deeper understanding of the molecular mechanisms underlying the BM onset has been gained, leading to the development of bone-targeting agents. So far, most of the research has been focused on the pathophysiology and treatment of BM, with o...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThere is an acute worsening of urinary symptoms among men receiving modern post-prostatectomy radiation. Worsening of urgency is associated with bladder dosimetry while flow, frequency, nocturia, and dysuria are not. This data can be used during treatment planning to reduce acute urinary toxicity during post-prostatectomy radiation.
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research
PROSTATE cancer has overtaken breast cancer to become the UK's most commonly diagnosed form of the disease. The development comes 10 years earlier than predicted after cases more than doubled in the past two decades, said Prostate Cancer UK.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02008
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Ground-breaking research, together with greater awareness - highlighted by the Daily Mail's End The Needless Prostate Deaths campaign - is changing the outlook for men with the condition.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibitor activation of an integrated stress response, drives the degradation of MCL1, and identify the mitochondria-associated ubiquitin ligase MARCH5 as the primary mediator of this NOXA-dependent MCL1 degradation. Therapies that enhance MARCH5-mediated MCL1 degradation markedly enhance apoptosis in response to a BH3 mimetic agent tar...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Source Type: research
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