Penis cancer therapy lets sufferers continue to have sex

Researchers from the Gustave Roussy Cancer Campus, France found treating penis cancer with radiotherapy may be a viable alternative to having parts of the genitals removed.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Radiation-induced erectile dysfunction (RI-ED) following prostate cancer radiation therapy is a significant survivorship problem. The etiology of this condition has been postulated to result from injury to the penile vessels, nerves or both. To address this gap in knowledge, we applied a vascular radioprotectant to a rat model of RI-ED. Protecting the vasculature did not improve erectile function or prevent nerve injury, suggesting a critical role for RT-mediated nerve damage in RI-ED.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Biology Contribution Source Type: research
Describe knowledge and risk perception of Human Papillomavirus (HPV) among deaf adults who use American Sign Language (ASL) in comparison to hearing adults in the United States.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
ConclusionThe current case highlights PBCC as a diagnostic pitfall which presented in a young adult with a normal PSA level.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
The prostate and bladder are the most common primary cancer sites for penile metastases. Here, we describe an unusual case of metastases from renal cell carcinoma to the penis discovered 1 month after nephrectomy in a 60-year-old man. The diagnosis was achieved using B-mode and contrast-enhanced ultrasound.
Source: Ultrasound Quarterly - Category: Radiology Tags: Correspondence Source Type: research
A 42 year old male patient presented to the outpatient department of our hospital with purulent discharge per urethra when voiding and a mass at the tip of the penis for the past 3 months. The patient had visited multiple practitioners of alternative medicine at his hometown before visiting our centre but had no relief in his symptoms along with a progression in the size of the mass. There was no history of any surgical intervention or intervention on the penis in the past. The patient was sexually active and monogamous.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSION: The results underscored the necessity to develop health education and promotion aimed at improving the knowledge and vaccination practice in immigrants and refugees. PMID: 30420043 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
We present a case of a patient with a giant primary penile cancer managed with radical penectomy, bilateral inguinal lymphadenectomy and perineal urethrostomy, who experienced disease recurrence 6 months after surgery and died with metastatic disease after denial of further treatment. The management of our case was challenging due to the extremely late diagnosis, the huge dimensions and the infiltrative nature of the tumour; however, from a histopathological perspective, the cancer itself did not display any microscopic peculiarity. Our case highlights that such bulky penile tumors can still occur in current urologic pract...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
For locally advanced (including inguinal and pelvic lymph node metastatic disease) and distant metastatic penile squamous cell carcinoma (PSCC), multimodal treatments utilizing surgery, chemoradiotherapy and/or chemotherapy continue to be the most popular treatment regimen. Although several chemotherapy regimens combined with surgery have achieved encouraging short-term efficacies, long-term survival for those patients remains poor [1,2]. For patients with chemotherapy-failed experience, therapeutic options are even more limited.
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Original article Source Type: research
This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5-33.4) including lichen ruber (12.0, 95% CI 3.0-48.0), indicating lichen ruber to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2-7.4), immunosuppressive drugs (5.0, 95% CI 2.5-9.8), penile surgical procedures (4.8, 95% CI 2.2-10.8), balanitis (9.2, 95...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
CONCLUSIONS: EGFR mono-antibody may be a potential modality for locally advanced PSCC patients after chemotherapy failure. Further large-scale clinical studies are needed to elucidate the role of human papillomavirus status and critical gene mutations in the clinical response to EGFR-targeted therapy. PMID: 30446465 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
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