Lymphoepithelioma-Like Carcinoma in Liver.

Lymphoepithelioma-Like Carcinoma in Liver. Am J Pathol. 2017 May 10;: Authors: Labgaa I, Stueck A, Ward SC Abstract Liver cancer, primarily encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second cause of worldwide cancer-related death during the past two decades. Lymphoepithelioma-like carcinomas (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymphoid infiltrate, and can arise in the liver as hepatocellular or cholangiocarcinoma forms. Patients with liver LELC display distinctive demographics and tumor characteristics. LELCs also appear to be associated with strikingly better outcomes compared to typical liver cancers, with 5-year survival rates of 57% to 100% versus 12% to 68%, respectively. Liver LELCs represent a unique model of immune response in liver cancer. Data on LELCs of the liver remain limited, and future comprehensive studies are needed to further elucidate this disease, which could ultimately offer precious insights for immunotherapeutic strategies in liver cancer. PMID: 28500863 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research

Related Links:

HEART disease: Around twice as many people are living with heart and circulatory diseases in the UK than with cancer and Alzheimer's disease combined according to the British Heart Foundation. Could a seemingly innocent and popular drug be contributing to these shocking statistics?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractGasdermins (GSDM) are members of a family of pore-forming effector proteins which lead to membrane permeabilization and pyroptosis, a lytic cell death with pro-inflammatory characteristics. Recently, two members of the gasdermin family, gasdermin B (GSDMB) and gasdermin E (GSDME), were shown to suppress tumor growth, through the involvement of cytotoxic lymphocytes. Other studies also reported the important functions of gasdermins in various cancer types including gastric cancer, hepatocarcinoma, and cervix and breast cancer. However, gasdermins have not been previously studied in the context of serous ovarian canc...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
This study provides pilot data for the further development ofL. casei exoproducts as an anti-inflammatory or anti-proliferative agent for the treatment of inflammatory and cancer diseases in gut. However, more data is needed before final conclusions ofL. casei cell-free supernatant ’s efficacy can be drawn.
Source: Inflammation - Category: Allergy & Immunology Source Type: research
More than two in five (42%) teaching assistants, caretakers, cleaners and other school support staff in England and Wales are actively looking for better paid jobs because of the rising cost of living and persistent low pay in education, according to a UNISON survey released today (Friday).  The survey responses paint a bleak picture of school employees living with no heating or hot water because of broken boilers they can’t afford to fix, worrying about how to pay for dental treatment, relying on their children for money, or going to food banks.  The findings reveal an overwhelming majority (96%) say the r...
Source: UNISON Health care news - Category: UK Health Authors: Tags: News Press release education Jon Richards schools Source Type: news
Health care costs in the U.S. have increased dramatically over the past five decades, from $74 billion in 1970 to $3.8 trillion in 2019. This trend has been fueled in large part by an increase in the number of people who struggle with chronic conditions such as cancer, diabetes, hypertension, and lung disease. Stanford UniversityRead more …How advanced analytics can help social determinants of health originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Policy Public Health & Source Type: blogs
Lab Chip, 2021, Advance Article DOI: 10.1039/D1LC00801C, PaperHyeono Nam, Hyung Jin Sung, Jinsoo Park, Jessie S. Jeon TSAWs quickly form a tumor spheroid for a drug screening platform. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Rout searched everywhere for a thoughtfully designed, stylish pill case to keep her medication and was disappointed to find plastic, highly medical options on the market. "In a world where you can buy almost anything online, it made me feel both as a consumer and a human being completely forgotten"
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Diversity, Equity & Inclusion /diversity-equity-inclusion Leadership /leadership Innovation /innovation Healthcare /healthcare Source Type: news
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Although advancements in cervical cancer prevention have helped reduce the incidence, mortality, and prevalence, access to these preventive services has not been experienced equally by all women in the United States. The purpose of this study was to learn about the factors that affect access to preventive services in a low-income, primarily Black community. Using a community-based participatory research approach, women were recruited to participate in 7 focus groups, with 6 to 8 women per group (N = 45). Participants were mainly Black (64%), with a mean age of 46 years, and 60% reporting completing at least some college. T...
Source: Family and Community Health - Category: Primary Care Tags: Original Articles Source Type: research
Liver cancer, primarily encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second cause of worldwide cancer-related death during the past two decades. Lymphoepithelioma-like carcinomas (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymphoid infiltrate, and can arise in the liver as hepatocellular or cholangiocarcinoma forms. Patients with liver LELC display distinctive demographics and tumor characteristics. LELCs also appear to be associated with strikingly better outcomes compared to typical liver cancers, with 5-year survival rates of 5...
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research
More News: Bile Duct Cancer | Cancer | Cancer & Oncology | Carcinoma | Cholangiocarcinoma | Epithelial Cancer | Hepatocellular Carcinoma | Liver | Liver Cancer | Pathology | Study | Undifferentiated Carcinoma | Urology & Nephrology