Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
Publication date: 30 June 2017 Source:International Journal of Pharmaceutics, Volume 526, Issues 1–2 Author(s): Pinaki Sengupta, Bappaditya Chatterjee The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved significantly. An increasing trend in topical nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their noninvasive delivery, avoidance of gastrointestinal side effects, easier applicability and good therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation can be considered as a potential and promising candidates for topical delivery of lipophilic drugs in the future. The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this r...
We would like to thank Drs. Lapostolle, Lecomte, Arnaudet, Javaudin, Pes, and Petrovic for their thoughtful comments regarding our paper “Ultrasound use during cardiopulmonary resuscitation is associated with delays in chest compressions.” They raise several important points regarding the paper that warrant clarification.
I read with interest the article by Goto et al.  assessing whether bystander compression-only cardiopulmonary resuscitation (CPR) is equivalent to conventional CPR in children with out-of-hospital cardiac arrest (OHCA). The study reports that conventional CPR was associated with improved outcomes compared to compression-only CPR in the majority of the subgroups following pediatric (1 –17 years old) OHCA. However, I have some concerns about the conclusion of this article.
Authors: Korkmaz A, Sahin D, Guray U Abstract AIM: Recently fragmented QRS (fQRS) on ECG has been introduced as a predictor of myocardial scarring and myocardial ischemia in coronary artery disease. OBJECTIVE: The aim of this study was to investigate the relationship between fQRS and fractional flow reserve (FFR) results in patients with the intermediate degree of coronary artery stenosis. METHODS: A total of 301 consecutive patients who underwent coronary angiography and FFR measurement for intermediate coronary artery stenosis were included in the study. The study patients were divided into two ...
CONCLUSION: The expression of Bmi-1 is associated with the progression and invasion of esophageal cancer. PMID: 29240461 [PubMed - as supplied by publisher]