Isolation and identification Candida vulvovaginitis in women referred to health centers of Arak City and antifungal activity of Equisetum arvense and Quercus on Candida albicans

This study investigated 152 patients suspicious of vulvovaginal candidiasis. Seventy-five isolates were identified from 152 isolates ofCandida albicans, and 55 yeast isolates were identified as non-albicans (Candida krusei,Candida glabrata, andCandida tropicalis), and 22 yeast isolates were unidentified. In broth microdilution method,MIC50 was reported as 12.5  μl/ml inCandida albicans forEquisetum arvense andQuercus, and MFC was reported as 25  μl/ml for both plants. In this research, isolation ofCandida albicans species is more than that of non-albicans species.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Authors: Negrini TC, Koo H, Arthur RA Abstract Oral cavity harbors a complex and highly diverse microbial community. Cross-kingdom interactions between Candida and oral bacteria are critical for their co-existence, which may also affect the course and the severity of biofilm-mediated bacterial-mediated diseases. C. albicans has been found in polymicrobial biofilms associated with denture stomatitis, oral mucositis, dental caries, periodontal diseases, peri-implantitis, and root canal infection. Thus, it is of utmost importance to unravel the mechanisms of Candida-bacterial interactions and their impact on the onset...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Bertolini M, Dongari-Bagtzoglou A Abstract Candida albicans is an opportunistic pathogen colonizing the oropharyngeal, esophageal, and gastrointestinal mucosa in most healthy humans. In immunocompromised hosts, this fungal organism can cause mucosal candidiasis in these sites. C. albicans also causes fungemia, a serious consequence of cancer cytotoxic chemotherapy, which is thought to develop from fungal translocation through compromised mucosal barriers. Changes in endogenous bacterial population size or composition as well as changes in the host environment can transform fungal commensals into opportunis...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusions: The PK simulations in this study suggest that transplant recipients on voriconazole prophylaxis against invasive candidiasis or aspergillosis are likely to achieve the target concentrations associated with the desired treatment outcomes if the maintenance dose is 200 mg twice daily. However, Aspergillus spp. with high minimal inhibitory concentrations could require higher maintenance doses.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
In this study, we aimed to evaluate the applicability of the novel formulation for the prevention of C. albicans colonization on denture material and development of clinical disease. To that end, using the latest technological advances in dental digital design and three-dimensional (3D) printing, we fabricated an intraoral device for rats with universal fit. The device was successfully installed and used to develop clinical DS. Importantly, by taking a preventative therapeutic approach, we demonstrated the potential clinical utility of the novel formulation as a safe and feasible prophylactic agent against DS.
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Fungal and Parasitic Infections Source Type: research
ConclusionThe anti-HSV-2 effect of JZ-1 was superior to that of penciclovir and berberine in vitro, and was mainly mediated by enhancing host cell defense and blocking adhesion and penetration of HSV-2.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 November 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Yihong Li
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention. That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report. The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance. Genetic research shows germs have become especially adep...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Featured Health Antibiotics Bacteria CNN Superbugs Source Type: news
AbstractPurpose of ReviewThe global emergence of antifungal resistance amongCandida spp. andAspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors for antifungal resistance is essential to retaining their clinical utility.Recent FindingsInvasive candidiasis is increasingly caused by non-albicans Candida species with reduced susceptibility to first-line antifungals, making empiric treatment decisions difficult. Echinocandin resistance inC. glabrata ...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
Molecules, Vol. 24, Pages 4151: Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones Molecules doi: 10.3390/molecules24224151 Authors: Witold Gładkowski Monika Siepka Tomasz Janeczko Edyta Kostrzewa-Susłow Jarosław Popłoński Marcelina Mazur Barbara Żarowska Wojciech Łaba Gabriela Maciejewska Czesław Wawrzeńczyk Six γ-oxa-ε-lactones, 4-phenyl-3,4-dihydro-2H-1,5-benzodioxepin-2-one (5a) and its five derivatives with methoxy groups in different positions of A and B rings (5b–f), were synthesized fr...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Abstract Lipases are a group of enzymes of considerable significance in organic synthesis, among which Candida antarctica lipase B (CALB) is one of the most widely studied enzymes. The activity of the biocatalyst has been intensively characterized in many organic media, but this paper aimed to compare the effect of 20 different solvents on the activity of CALB in the hydrolysis of p-nitrophenyl laurate. Nonpolar, polar aprotic, and polar protic solvents were used for enzyme pretreatment and then entered the composition of mixed solvents reaction medium. An impact of solvents on solvation processes affecting the ca...
Source: Bioprocess and Biosystems Engineering - Category: Biomedical Engineering Authors: Tags: Bioprocess Biosyst Eng Source Type: research
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