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Identification of the neuronal suppressor of cataplexy, sudden weakening of muscle tone

Narcolepsy is a disorder caused by losing orexin neurons, marked by excessive daytime sleepiness and cataplexy, sudden weakening of muscle tone. Previously, we found two kinds of neurons preventing narcolepsy by receiving information from orexin neurons. Here, we have discovered that serotonin neuron, one of the two neurons above, inhibits cataplexy by reducing the amygdala activity, which controls emotion. Current discovery should lead to comprehension of the narcolepsy mechanism and to therapy development for cataplexy.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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AbstractModafinil, an FDA approved wakefulness drug prescribed to narcolepsy patients, has recently been shown to have anti-inflammatory effects and provides protection against neuroinflammation. It is unknown if modafinil can also protect against atherosclerosis, pathogenesis of which implicates inflammation. Using an apoE-deficient mouse model, we tried to elucidate the effects of modafinil treatment on the development of atherosclerosis. We tested serum levels of cytokines. We isolated mouse bone marrow-derived macrophages (BMDMs), detected effect of modafinil on the viability and proliferation of BMDMs, and on oxidized...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsPediatric patients with EDS had various sleep disorders and some did not have any sleep disorder despite EDS. More than half the patients with EDS showed depressive feelings affecting their daily lives. For pediatric patients with EDS, a systematic diagnostic approach including questionnaires for sleep habits and emotion and PSG is essential for accurate diagnosis and treatment.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
CONCLUSIONS: Pediatric patients with EDS had various sleep disorders and some did not have any sleep disorder despite EDS. More than half the patients with EDS showed depressive feelings affecting their daily lives. For pediatric patients with EDS, a systematic diagnostic approach including questionnaires for sleep habits and emotion and PSG is essential for accurate diagnosis and treatment. PMID: 28822033 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
Current diagnostic criteria of narcolepsy types 1 (NT1), type 2 (NT2) and idiopathic hypersomnia (IH), including clinical, electrophysiological and biologic criteria are listed in the International classification of sleep disorders, 3rd edition (ICSD-3). Electrophysiological criteria have been recently weakened with the demonstration that the multiple sleep latency test (MSLT) has poor test/retest reliability. Thus the search for additional electrophysiological criteria for these central disorders of hypersomnolence.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Symposium XV. – Registering sleep objectively Source Type: research
s JP Abstract Histamine H3 receptor (H3R) is associated with several neuropsychological diseases. It is predominantly expressed in the central nervous system as presynaptic receptor, especially in regions associated with cognition and behavior, and is responsible for modulate the synthesis and release of histamine and other neurotransmitters such as acetylcholine, dopamine and serotonin. Therefore, H3R is an important target involved in several CNS disorders, such as narcolepsy, attention deficit hyperactivity disorder and schizophrenia. H3R antagonists/inverse agonists have also demonstrated pro-cognitive effects...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
We report two cases of fathers whose parental fitness was questioned during divorce and custody litigation because of narcolepsy type 2 and type 1, respectively. These cases highlighted both the existence of a narcolepsy-related stigma and the need to involve sleep experts in custody assessments when concerns about the parental fitness are related to a sleep disorder, expanding the field of interest of the growing“sleep forensics.”Citation:Barbero L, Govi A, Pizza F, Plazzi G, Ingravallo F. Parental fitness questioned on the grounds of narcolepsy: presentation of two cases.J Clin Sleep Med. 2017;13(8):1017–1018.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
RESUMO Objetivo: Revisar de modo sistem ático a utilização da Pediatric Daytime Sleepiness Scale (PDSS) na análise da sonolência diurna em crianças e adolescentes. Fontes de dados: Foram consultadas as bases de dados eletrônicas PubMed e SciELO, no período delimitado entre 2003 e 2015. Como critério de inclusão, foram consider ados estudos em inglês, espanhol e português; artigos originais de qualquer tipo de escopo, com amostra de crianças e/ou adolescentes e que utilizaram a PDSS. Foram excluídos artigos duplicados, sem rela&cce...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
ConclusionsCompared with the prepandemic background incidence rate, the number of incident narcolepsy cases was 3.8‐fold and 2.8‐fold as high.
Source: Pharmacoepidemiology and Drug Safety - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL REPORT Source Type: research
Teens are a notoriously sleepy bunch. Left to their own devices, many will happily snooze into the early hours of the afternoon. About 28 percent of teens also report falling asleep in school at least once a week, according to a poll by the National Sleep Foundation. This can make it difficult for parents to know when a teenager’s love affair with sleep might be the sign of narcolepsy or another sleep disorder. While narcolepsy is a rare condition, affecting only about .05 percent of the U.S. population, it often goes undiagnosed. It is a condition that typically develops between ages 10 and 20. “Patients with ...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Center for Pediatric Sleep Disorders Dr. Kiran Maski insomnia Narcolepsy Source Type: news
Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Authors: Source Type: research
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