MAIT cells and MR1-antigen recognition.

MAIT cells and MR1-antigen recognition.
Curr Opin Immunol. 2017 May 08;46:66-74
Authors: Keller AN, Corbett AJ, Wubben JM, McCluskey J, Rossjohn J
Abstract
Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector potential. Recent data demonstrates how: vitamin B precursors modulate intracellular trafficking of MR1 and impact on MAIT cell development; variation in the MAIT cell antigen receptor sequence impacts MR1-antigen recognition; and most notably, how MR1 can capture chemical identities distinct from riboflavin precursors, including drugs and drug-like molecules. With mounting evidence demonstrating their roles in immunity and pathology, understanding the MAIT-MR1-antigen axis may have profound implications for human diseases.
PMID: 28494326 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Keller AN, Corbett AJ, Wubben JM, McCluskey J, Rossjohn J Tags: Curr Opin Immunol Source Type: research