New pyranonaphthazarin and 2-naphthoic acid derivatives from the mangrove endophytic fungus Leptosphaerulina sp. SKS032

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Hui Cui, Yena Liu, Meng Ding, Zhengrui Zhang, Huiting Liu, Xishan Huang, Zhigang She Two new compounds, named leptospyranonaphthazarin A (1) and leptosnaphthoic acid A (2), together with four known compounds (3–6) were isolated from an endophytic fungus Leptosphaerulina sp. SKS032. Their structures were assigned using spectroscopic methods, computational methods, and single-crystal X-ray diffraction analysis. In the antibiotic assay, compounds 1, 2, and 6 exhibited antibacterial activities against Staphylococcus aureus with minimal inhibitory concentration (MIC) values of 25.0, 50.0, and 50.0μg/mL, respectively. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research