Dyspepsia and the microbiome: time to focus on the small intestine

We note with interest two recent publications in Gut regarding alterations to the gut microbiome in individuals on proton pump inhibitor (PPI) therapy.1 2 With PPI use, both studies observed an increase in oral bacteria in the stool. These changes overlap with those described in patients with cirrhosis of the liver.3 However, very little is known about the impact of this dysbiosis over the length of the GI tract, and how it may link to gut function. While the data from both Jackson et al1 and Imhann et al2 are demonstrative of a shift towards oral-associated bacteria, it is important to note that many of these bacteria have also been identified in the stomach and small intestine. Recently, we have shown that although the microbiota found in the healthy duodenum are taxonomically similar to the oral microbiota, their presence...
Source: Gut - Category: Gastroenterology Authors: Tags: PostScript Source Type: research

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Condition:   Non-alcoholic Steatohepatitis (NASH) Intervention:   Procedure: Endoscopic vertical gastroplasty Sponsor:   Instituto de Investigación Marqués de Valdecilla Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Dementia;   Chronic Disease;   Neoplasm Metastasis;   Lung Neoplasm;   Pulmonary Disease, Chronic Obstructive;   Heart Failure,Congestive;   Liver Cirrhosis;   Kidney Failure, Chronic;   Lung Diseases, Interstitial;   Peripheral Vascular Disease;   Diabetes With End  Organ Injury;   Palliative Care, Patient Care;   Health Care Quality, Access, and Evaluation;   Patient Care;   Inpatients;   Healt...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Patients with liver cirrhosis may develop hepatic encephalopathy. Rats with chronic hyperammonemia exhibit neurological alterations mediated by peripheral inflammation and neuroinflammation. Motor incoordinati...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Biliary atresia (BA), which is the most important cause of liver cirrhosis in children, is characterized by progressive fibro-obliterative inflammation involving the extra- and intrahepatic bile ducts in infancy.1 A successful Kasai portoenterostomy procedure establishes bile drainage and may  prevent hepatic fibrogenesis and the need for liver transplantation. However, the procedure is unsuccessful in a significant portion of patients, who have persistent jaundice and liver dysfunction. Intestinal bile acids modulate the gut microbiota and may have a role in disease progression in BA.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research
ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in end-stage renal disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Conclusion: thus, liver diseases were diagnosed in 29% of COPD patients. The presence of clinical signs of liver disease in patients with COPD requires additional examination and mandatory medical correction.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in End Stage Renal Disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Conclusion: In Mongolia, the prevalence of H. pylori resistance is high requiring bismuth quadruple therapy or susceptibility-based therapy to obtain acceptable cure rates. Introduction As in most developing countries, the prevalence of Helicobacter pylori infection is high in Mongolia (Nyamdavaa, 2013) with reported prevalence ranging of 80% among adults (Matsuhisa et al., 2015; Khasag et al., 2018), 64% among adolescents, and 65 and 100% among pediatric patients with gastric comorbidity (Go, 2013). Gastric cancer is a common problem in Mongolia; an age-standardized rate of 33.1 per 100,000, which is the second hi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: DAA treatment of chronic hepatitis C genotype 1b and 2a resulted in a high rate of sustained virologic response and improvement of liver fibrosis score. PMID: 30419644 [PubMed - in process]
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
Publication date: Available online 29 December 2016 Source:Steroids Author(s): Fayaz Ali Larik, Aamer Saeed, Danish Shahzad, Muhammad Faisal, Hesham El-Seedi, Haroon Mehfooz, Pervaiz Ali Channar Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressureandheart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. The therapeutic mechanism ...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
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