Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer

Conclusions
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS. The effects of RAF1 are kinase-dependent, but MEK-independent. Despite the lack of activating mutations in RAF1, its kinase domain is an attractive therapeutic target for CRC.

Source: Gut - May 12, 2017 Category: Gastroenterology Authors: Borovski, T., Vellinga, T. T., Laoukili, J., Santo, E. E., Fatrai, S., van Schelven, S., Verheem, A., Marvin, D. L., Ubink, I., Borel Rinkes, I. H. M., Kranenburg, O. Tags: Colon cancer Source Type: research