{alpha}-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors

Conclusions Vc1.1-mediated activation of GABABR is a novel mechanism for reducing the excitability of human DRG neurons. Vc1.1-induced activation of GABABR on the peripheral endings of colonic afferents reduces nociceptive signalling. The enhanced antinociceptive actions of Vc1.1 during CVH suggest it is a novel candidate for the treatment for CVP.

http://gut.bmj.com/cgi/content/short/66/6/1083?rss=1

Source: Gut - May 12, 2017 Category: Gastroenterology Authors: Castro, J., Harrington, A. M., Garcia-Caraballo, S., Maddern, J., Grundy, L., Zhang, J., Page, G., Miller, P. E., Craik, D. J., Adams, D. J., Brierley, S. M. Tags: Open access Neurogastroenterology Source Type: research