Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Conclusions NPC1 confers increased risk of early-onset severe CD. Our data support the concept that genetic defects at different checkpoints of selective autophagy cause a shared outcome of CD-like immunopathology linking monogenic and polygenic forms of IBD. Muramyl dipeptide-driven cytokine responses and antibacterial autophagy induction are parallel and independent signalling cascades downstream of the NOD2-RIPK2-XIAP complex.
Source: Gut - Category: Gastroenterology Authors: Tags: Crohn's disease, Open access Inflammatory bowel disease Source Type: research

Related Links:

Feuerstein et  al1 conclude that chromoendoscopy is superior to standard-definition white-light endoscopy (SDWLE) but not superior to high-definition white-light endoscopy (HDWLE) in patients with inflammatory bowel disease. They base this conclusion on an analysis of 2 subgroups (chromoendoscopy vs SDWLE and ch romoendoscopy vs HDWLE) within their meta-analysis of randomized trials of chromoendoscopy versus white-light endoscopy. However, their interpretation of this subgroup analysis is incorrect.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Authors: Ingawale DK, Mandlik SK Abstract Inflammation is a physiological intrinsic host response to injury meant for removal of noxious stimuli and maintenance of homeostasis. It is a defensive body mechanism that involves immune cells, blood vessels and molecular mediators of inflammation. Glucocorticoids (GCs) are steroidal hormones responsible for regulation of homeostatic and metabolic functions of body. Synthetic GCs are the most useful anti-inflammatory drugs used for the treatment of chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), allergies, multiple sclerosis, te...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
In conclusion, the integrated strategy provides novel insights into network pharmacology and metabolomics as effective tools to illuminate the mechanism of action of TCM. PMID: 32070601 [PubMed - in process]
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract PURPOSE: To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats. METHODS: Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administration of 4% acetic acid (AA). 5mg/kg/day adenosine was performed i.p for 4 weeks to AC+AD group. Rectum and colon were excised for microscopic and histopathological histopathologic evaluations, and immunohistochemical analysis of nuclear factor kappa B (NF-kB). Blood samples were collected for biochemical detectio...
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
Condition:   Ulcerative Colitis Intervention:   Biological: Brazikumab Sponsor:   Allergan Not yet recruiting
Source: - Category: Research Source Type: clinical trials
This study aimed to determine the radiation dose associated with percutaneous drainage and follow-up in the setting of IBD and identify risk factors associated with high exposure.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
INTRODUCTIONCrohn's Disease (CD) results from chronic inflammation of the gastrointestinal (GI) tract involving TNF ‐α release. Gastrointestinal electrical stimulation (GES), a form of neuromodulation used to treat upper GI motility symptoms (UGI Sx), exerts an anti‐inflammatory effect via TNF‐α suppression. We hypothesized patients with CD symptoms in patients with gastroparesis (GP) may respond to GES.METHODSWe retrospectively examined 284 patients with symptomatic gastroparesis (Gp Sx), who underwent GES placement. Patients with Gp Sx were evaluated by validated GI Sx patient reported outcome. Scores w...
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Clinical Research Source Type: research
Abstract One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relationship between the genetic composition of the host and the intestinal microbiota, under impact of specific environmental factors, lead to chronic intestinal inflammation. Genome-wide association studies, followed by functional studies, have identified a role for numerous autophagy genes in IBD, especially in Crohn disease. Studies using in vitro and in vivo models, in addition to human clinical studies have revealed that autophagy is pivotal for intestinal homeostasis...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Nature Reviews Gastroenterology &Hepatology 13, 251 (2016). doi:10.1038/nrgastro.2016.55 Author: Iain Dickson Patients with the neurodegenerative lysosomal lipid storage disorder Niemann-Pick disease type C1 (NPC1) can present with IBD, but the functional mechanism of this association was previously unclear. New findings now shed light on this link, showing that impaired induction of autophagy resulting in defective clearance
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Research Highlight Source Type: research
Charlea Armstead's genetic disorder puts Victoria Lambert in mind of a fragile octogenarian. Not so her extraordinary spirit
Source: Telegraph Health - Category: Consumer Health News Tags: niemann-pick alzheimers crohns 12-year-old dementia Source Type: news
More News: Brain | Crohn's Disease | Genetics | Inflammatory Bowel Disease | Liver | Neurology | Niemann-Pick Disease | Urology & Nephrology