The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

Conclusions Our results suggest that an altered microbiota composition mediated by a specific host genotype can contribute to the development of MetS.
Source: Gut - Category: Gastroenterology Authors: Tags: Gut microbiota Source Type: research

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Publication date: March–April 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 14, Issue 2Author(s): Ranil Jayawardena, Yasindu C. Waniganayake, Sachith A. Abhayaratna, Priyanga RanasingheAbstractObjectiveThe study aimed to develop and validate a percentage body fat (%BF) prediction equation using SFT for Sri Lankan adults.MethodsHealthy adults (≥18 years) were randomly selected and SFT was measured in five areas (triceps, biceps, calf, suprailliac and subscapular). Body composition analysis was evaluated by Deuterium oxide (D2O) dilution. Prediction equation for %BF was derived...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
In this long ‐term follow‐up of women with GDM, we found that 2‐hour glucose during OGTT at pregnancy predicted β‐cell function (as measured by ODI) 22 years post‐partum. Results of 2‐hour glucose during OGTT at pregnancy is a more useful indicator of long‐term metabolic risk. Most of the cases wh ich later converted to type 2 diabetes occurred within the first 15 years postpartum. AbstractAims/IntroductionWomen with gestational diabetes mellitus are at increased risk for type  2 diabetes. We characterized the association between maternal glycemia during pregnancy with long‐term outcomes.Methods a...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
AbstractObesity and insulin resistance are at the centre of most cases of metabolic syndrome (MetS), which may increase the risk of cardiovascular disease approximately 2 ‐fold and type 2 diabetes mellitus approximately 5‐fold. Aside from lifestyle intervention and drug therapy, bariatric surgery (BS) is considered a definitive treatment for this disease.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: JDI UPDATES Source Type: research
Publication date: Available online 20 February 2020Source: Seminars in Cancer BiologyAuthor(s): Licia Iacoviello, Marialaura Bonaccio, Giovanni de Gaetano, Maria Benedetta DonatiAbstractBreast cancer is the leading cause of death in women aged 20 to 50 years, with some geographical difference. The yearly incidence of the disease is increasing while the related mortality is steadily decreasing. Breast cancer is associated not only with specific hormones or factors related with reproduction, but mostly to more general environmental factors, linked to socioeconomic conditions and lifestyles (smoking, stress, physical exercise...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
CONCLUSIONS: Variables significantly predictive of MetS were age, male gender, African-American ethnicity, BMI, and lycopene intake. PMID: 32067763 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Authors: Warmbrunn MV, Herrema H, Aron-Wisnewsky J, Soeters MR, Van Raalte DH, Nieuwdorp M Abstract Introduction: Cardiometabolic diseases (CMD) are a group of interrelated disorders such as metabolic syndrome, type 2 diabetes mellitus and cardiovascular diseases (CVD). As the prevalence of these diseases increases globally, efficient new strategies are necessary to target CMD and modifiable risk factors. In the past decade, evidence has accumulated regarding the influence of gut microbiota (GM) on CMD, providing new targets for therapeutic interventions.Areas covered: This narrative review discusses the pathophysi...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Authors: Yang HS, Hur M, Kim H, Kim SJ, Shin S, Di Somma S, GREAT Network Abstract BACKGROUND: High-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a population with high HDL-C levels. METHODS: A total of 300 Korean individuals with high HDL-C levels (≥2.331 mmol/L) were enrolled following a comprehensive general medical examination including body composition analysis. HDL3-C levels were measured using the HDL3-EX SEIKEN kit (Randox Ltd., Cr...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
ConclusionsConsidering major health and economic problems posed by unrestrained diabetes epidemic in India, research in this area remains highly inadequate.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionThere was an increase in the prevalence of neuroischemic DFU. The Enterobacteriaceae family replaced SA as the most prevalent pathogen in DFI, with an increase in the isolation of gram-negative microorganisms and mixed polymicrobial cultures. Chronic neuroischemic infected ulcers usually present distinct bacterial isolates; knowledge about the most common agents is warranted in order to better select empiric antibiotic therapy.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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