Investigation of nanocarriers and excipients for preparation of nanoembedded microparticles
In this study, different polymer nanocarriers (poly(lactide-co-glycolide), poly(styrene), chitosan and dendrimers) were used for preparing NEMs by spray-drying. Further, distinct matrix excipients were investigated including sugars (i.e., trehalose, sucrose, mannitol) and polymers (poly(vinyl pyrrolidone) and poly(ethylene glycol)), and the characteristics and performance of NEMs were studied in detail. It was found that with increasing hydrophilicity of the polymer nanocarriers, an increasing amount of excipient was necessary to stabilize the nanoparticles. NEMs containing polyplexes and nanogels required a matrix-to-nanoparticle (M:N) ratio of 50:1 and 10:1, respectively, whereas NEMs with poly(styrene) and poly(lactide-co-glycolide) only required an M:N ratio of 1:1 and 1:4, respectively. Investigation of different excipients demonstrated that water soluble sugars and polymers can be used to prepare NEMs and that spray-dried amorphous excipients (trehalose, sucrose, poly(vinyl pyrrolidone)) are superior to spray-dried crystalline excipients (mannitol, poly(ethylene glycol)) for stabilizing NEMs. It is therefore important to select an appropriate excipient for stabilization of a given nanoparticle system and identify a suitable level of this excipient to keep the nanoparticles viable. Graphical abstract
Authors: Mendoza De La Garza M, Tieu C, Schroeder D, Lowe K, Tung E Abstract Medical schools throughout the country struggle with how best to train students to provide quality, patient-centered care to the burgeoning population of older adults. The Senior Sages Program (SSP) is a longitudinal Senior Mentor Program (SMP) that offers students the opportunity to learn about the aging process and core geriatric medicine concepts through the eyes of an aging expert: their Senior Sage. The SSP marries a robust electronic curriculum with an SMP and online discussion board. The aim of this program evaluation was to measure...
A single hailstorm changed me from rational to irrational... The post How to Use Framing to Sell More Warranties and Service Contracts appeared first on Neuromarketing.
Discussion When men enacted female-typical caregiving roles, their retirement timing resembled women's. Eldercare, in particular, was associated with earlier retirement timing. Implications for individual retirement decision-making and policy are discussed. PMID: 29911387 [PubMed - as supplied by publisher]
The former Tory leader has urged his party to consider legalising recreational use of the drug.
According to Toronto-based scholar Dr Jeanette Bicknell from York University, people's feelings about their use of time contributes to wellbeing as much as their wealth.
STOMACH bloating is caused by eating something that your stomach disagrees with, or something that you're allergic to. It involves a swelling in the stomach which can be painful. Juicing guru, Jason Vale, recommended trying this drink on ITV's This Morning to help beat the bloat.
LONDON (Reuters) - Britain said on Tuesday it had no intention of legalizing cannabis after a former leader of Prime Minister Theresa May's party said the government had "irreversibly lost" the battle to drive the drug off the streets.
Researchers from the Centers for Disease Control and Prevention in Atlanta, Georgia, found HIV tests can give false negative results for up to seven months among those taking PrEP.
CONCLUSION: Childhood cholesteatoma was more extensive and destructive compared to adults, representing a more aggressive disease in this cohort. PMID: 29909808 [PubMed - as supplied by publisher]
CONCLUSION: The results show a good correlation between the pre-operatively predicted insertion depths using the software application and those post-operatively measured using X-ray. The insertion length predicted by the software was always longer than that measured via X-ray. PMID: 29909807 [PubMed - as supplied by publisher]