Investigation of nanocarriers and excipients for preparation of nanoembedded microparticles
In this study, different polymer nanocarriers (poly(lactide-co-glycolide), poly(styrene), chitosan and dendrimers) were used for preparing NEMs by spray-drying. Further, distinct matrix excipients were investigated including sugars (i.e., trehalose, sucrose, mannitol) and polymers (poly(vinyl pyrrolidone) and poly(ethylene glycol)), and the characteristics and performance of NEMs were studied in detail. It was found that with increasing hydrophilicity of the polymer nanocarriers, an increasing amount of excipient was necessary to stabilize the nanoparticles. NEMs containing polyplexes and nanogels required a matrix-to-nanoparticle (M:N) ratio of 50:1 and 10:1, respectively, whereas NEMs with poly(styrene) and poly(lactide-co-glycolide) only required an M:N ratio of 1:1 and 1:4, respectively. Investigation of different excipients demonstrated that water soluble sugars and polymers can be used to prepare NEMs and that spray-dried amorphous excipients (trehalose, sucrose, poly(vinyl pyrrolidone)) are superior to spray-dried crystalline excipients (mannitol, poly(ethylene glycol)) for stabilizing NEMs. It is therefore important to select an appropriate excipient for stabilization of a given nanoparticle system and identify a suitable level of this excipient to keep the nanoparticles viable. Graphical abstract
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Mazars USA LLP is expected to start work Monday at District-owned United Medical Center after D.C. Council members approved the company's operating contract late Friday. It followed a D.C. Council health committee hearing earlier that day, when officials from the New York-based auditing firm worked to prove they were the right pick for a $5 million, eight-month contract to oversee operations at the hospital and replace previous, controversial operator, Veritas of Washington LLC. "We know that…
CONCLUSION: The newly developed questionnaire can facilitate the diagnosis in patients with suspicion on interstitial lung disease in clinical routine. PMID: 29466814 [PubMed - as supplied by publisher]
Authors: Kropp R PMID: 29466813 [PubMed - as supplied by publisher]
This report is describing the case of a patient who developed parallel two different mechanisms of resistance: A T790 M resistance mutation and a transformation into a small cell neuroendocrine cancer. Under therapy with Osimertinib and chemotherapy with carboplatin and etoposide the tumor responsed partially. PMID: 29466812 [PubMed - as supplied by publisher]
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Soft Matter, 2018, Accepted Manuscript DOI: 10.1039/C7SM02317K, PaperAvinash Yashwant Gahane, Pritish Ranjan, Virender Singh, Raj Kumar Sharma, Neeraj Sinha, Mandeep Sharma, Rama Chaudhry, Ashwani Kumar Thakur A In the quest for new antimicrobial materials, hydrogels of Fmoc-protected peptides and amino acids have gained momentum due to their ease of synthesis and being cost effective. But their... The content of this RSS Feed (c) The Royal Society of Chemistry
J. Mater. Chem. A, 2018, Accepted Manuscript DOI: 10.1039/C7TA11095B, PaperIl Jeon, Ryohei Sakai, Seungju Seo, Graham Edward Morse, Hiroshi Ueno, Takafumi Nakagawa, Yang Qian, Shigeo Maruyama, Yutaka Matsuo High-performance air-stable PBTZT-stat-BDTT-8 organic solar cells were fabricated using mixed C60/C70 fullerene acceptors. Normal-architecture devices using PBTZT-stat-BDTT-8 with PC71BM produced a power conversion efficiency (PCE) of 9.38%. Inverted-architecture, which possess... The content of this RSS Feed (c) The Royal Society of Chemistry
CrystEngComm, 2018, Accepted Manuscript DOI: 10.1039/C7CE02189E, CommunicationRen-Bin Zhou, Xiao-Li Lu, Chen Dong, Ahmad Fiaz, Chen-Yan Zhang, Da-Chuan Yin Protein crystallization screens are commonly used to find specific crystallization conditions. In practice, the undesirable clear drops are often ignored. We hypothesize that clear drops may be potentially useful for... The content of this RSS Feed (c) The Royal Society of Chemistry
A new mother says she pulled blood-soaked bandages from her body, seven weeks after giving birth.