Solid nanofoams based on cellulose nanofibers and indomethacin —the effect of processing parameters and drug content on material structure
Publication date: 30 June 2017 Source:International Journal of Pharmaceutics, Volume 526, Issues 1–2 Author(s): J. Bannow, J.-W. Benjamins, J. Wohlert, K. Löbmann, A.J. Svagan The unique colloidal properties of cellulose nanofibers (CNF), makes CNF a very interesting new excipient in pharmaceutical formulations, as CNF in combination with some poorly-soluble drugs can create nanofoams with closed cells. Previous nanofoams, created with the model drug indomethacin, demonstrated a prolonged release compared to films, owing to the tortuous diffusion path that the drug needs to take around the intact air-bubbles. However, the nanofoam was only obtained at a relatively low drug content of 21wt% using fixed processing parameters. Herein, the effect of indomethacin content and processing parameters on the foaming properties was analysed. Results demonstrate that a certain amount of dissolved drug is needed to stabilize air-bubbles. At the same time, larger fractions of dissolved drug promote coarsening/collapse of the wet foam. The pendant drop/bubble profile tensiometry was used to verify the wet-foam stability at different pHs. The pH influenced the amount of solubilized drug and the processing-window was very narrow at high drug loadings. The results were compared to real foaming-experiments and solid state analysis of the final cellular solids. The parameters were assembled into a processing chart, highlighting the importance of the right combination of processing pa...
Chun Peng, Yan-Ling Wang
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Shirley Telles, Sachin K. Sharma, Niranjan Kala, Sushma Pal, Ram K. Gupta, Acharya Balkrishna
The government needs to take action to stop prescription drugs, including opioids and slimming tablets, being obtained from online pharmacies that can avoid regulation.
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Xuan Xie, Jun Jiang, Wenchu Ye, Ruohong Chen, Yiqun Deng, Jikai Wen
Ning Li, Heng Zhou, Qizhu Tang
Gantumur Battogtokh, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang
Juan F. Garc ía-Henares, Jose A. Moral-Munoz, Alejandro Salazar, Esperanza Del Pozo
Authors: Schaefer A, Lubos E, Pietzsch JB, Pietzsch M, Weber S, Blankenberg S, Reichenspurner H, Schäfer U, Conradi L Abstract AIMS: The German healthcare system was among the first to introduce transcatheter mitral valve repair (TMVR) in routine care. Objective of this study was to analyze adoption and utilization patterns and to estimate impact of TMVR availability on mitral valve (MV) procedure volumes in the first 8 years after commercialization. METHODS AND RESULTS: Procedure volumes were collected from German Federal Statistics Office databases for TMVR and mitral valve surgery (MVS) from 2008-2015. ...