Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies

ConclusionExisting observational studies support a significant association between depth of anesthesia (as measured by BIS) and long-term mortality ( ≥ one year), although it was without statistical significance at 30 days. Larger prospective, randomized trials are necessary to establish a definitive conclusion about whether this association represents true causality or is an epiphenomenon.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research