Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.

CONCLUSION: Here we show that fgl2(Tg) Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2(Tg) Treg prevent colitis in contrast to fgl2(+/+) Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease.
PMID: 28487604 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Bartczak A, Zhang J, Adeyi O, Amir A, Grant D, Gorczynski R, Selzner N, Chruscinski A, Levy GA Tags: World J Gastroenterol Source Type: research