Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder
Publication date: 30 June 2017 Source:International Journal of Pharmaceutics, Volume 526, Issues 1–2 Author(s): Yannick Guinet, Laurent Paccou, Florence Danède, Patrick Derollez, Alain Hédoux Valsartan is an antihypertensive drug, recognized to be marketed in an amorphous state, different from that obtained by quenching the liquid state below T g. This is an unusual and very original situation, given that the amorphous state is unstable. Low-wavenumber Raman spectroscopy and X-ray diffraction investigations were carried out on the various solid-state forms of valsartan. It was found that the marketed form is not amorphous and can be described in terms of mesophase in which the long-range order of the stable crystal is limited on the lengthscale of tens nanometers, inducing a melting temperature lower than that of the stable crystalline state, inherent to the crystallite size. This unusual physical state of a marketed drug was correlated to the relative population of cis–trans conformers, preventing the development of the hydrogen-bond network distinctive of the long-range order in the crystalline state. Graphical abstract
ConclusionsSpinach irrigated with RHW did not significantly affect the populations of fecal indicator bacteria when compared to CW‐irrigated spinach. Repeat irrigation with RCW is not recommended due to increased contamination of E. coli on spinach leaves. Significance and Impact of the StudyRHW may potentially be used as alternative irrigation water without deleteriously affecting the microbiological safety of the spinach.This article is protected by copyright. All rights reserved.
This study suggests that the optimized medium is not only effective but also economical for HSAF production. This article is protected by copyright. All rights reserved.