715. Neurons from Bipolar Disorder Patients Are Characterized by Intrinsically Different Sub Populations of Neurons

Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have challenged the development of animal and cellular models. We recently reported that hippocampal dentate gyrus (DG) neurons differentiated from induced pluripotent stem cell (iPSC)-derived fibroblasts of BD patients are electrophysiologically hyperexcitable.

Source: Biological Psychiatry - May 11, 2017 Category: Psychiatry Authors: Fred Gage, Shani Stern, Renata Santos, Maria Carol Marchetto, Ana Diniz Mendes, Guy Rouleau, Steven Biesmans, Qiuwen Wang, Jun Yao, Patrick Charnay, Anne Bang, Martin Alda Tags: SYMPOSIUM Source Type: research