Trans-generational neurochemical modulation of methamphetamine in the adult brain of the Wistar rat.

Trans-generational neurochemical modulation of methamphetamine in the adult brain of the Wistar rat. Arch Toxicol. 2017 May 05;: Authors: Fujáková-Lipski M, Kaping D, Šírová J, Horáček J, Páleníček T, Zach P, Klaschka J, Kačer P, Syslová K, Vrajová M, Bubenikova-Valešová V, Beste C, Šlamberová R Abstract Chronic methamphetamine (METH) abuse has been shown to elicit strong neurotoxic effects. Yet, with an increasing number of children born to METH abusing mothers maturing into adulthood, one important question is how far do the neurotoxic effects of METH alter various neurotransmitter systems in the adult METH-exposed offspring. The purpose of this study was to investigate long-term trans-generational neurochemical changes, following prenatal METH exposure, in the adult Wistar rat brain. METH or saline (SAL-control animals) was administered to pregnant dams throughout the entire gestation period (G0-G22). At postnatal day 90, dopamine, serotonin, glutamate and GABA were measured in the adult brain before (baseline) and after a METH re-administration using in vivo microdialysis and liquid chromatography/mass spectrometry. The results show that METH-exposure increased basal levels of monoamines and glutamate, but decreased GABA levels in all measured brain regions. Acute challenge with METH injection in the METH-exposed group induced a lower increase in the monoamine system relative to the increase in the GABAergic and ...
Source: Archives of Toxicology - Category: Toxicology Authors: Tags: Arch Toxicol Source Type: research