General health status of long-term cervical cancer survivors after radiotherapy

AbstractPurposeTo evaluate the global health status of long-term cervical cancer survivors (LCCS) who survived for more than 4  years after curative radiation treatment (RT).Patients and methodsMedical records of 562  women treated with RT in our institution between 2003 and 2010 were reviewed. Excluding 259 women who died of disease or were lost to follow-up, disease status and late morbidities were evaluated in 303 LCCS. Quality of life (QoL) was analyzed in 168 LCCS using a questionnaire from the Europea n Organization for the Research and Treatment of Cancer, and the results were compared with an age-matched healthy Korean female population.ResultsMedian follow-up was 6.8  years (range 4.1–12.5 years). There were 14 deaths (7 cancer specific) and 14 recurrences (5 local recurrences and 9 distant metastases). The median time to recurrence was 6.0 years (range 4.1–8.2 years). Grade ≥2 late toxicities were frequently observed in the bladder (19%) and sm all/large intestine (15%). Multivariate analysis revealed a higher rate of late toxicity in patients aged ≥51 years at diagnosis (small/large intestine: hazard ratio, HR, 2.5 [1.2–5.5]; bladder: HR 2.4 [1.3–4.5]; and bone: HR 4.3 [1.2–15.8]) than patients aged
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research

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Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
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Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
AbstractA  70-year old male with stage I large cell neuroendocrine carcinoma (LCNEC) of the lung underwent resection of a metachronous 5 cm brain metastasis and received postoperative hypofractionated stereotactic radiotherapy (hfSRT). Five sequential nodular leptomeningeal metastases up to 5.3 cm in di ameter were diagnosed on MRI within 10 months and were treated with SRT. Currently the patient has no evidence of intracranial disease 24 months after last irradiation without chemotherapy or whole brain radiotherapy. This is the first report of sustained complete remission of multiple large lepto me...
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
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Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
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Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
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