Cervical spine radiology
Publication date: Available online 9 May 2017 Source:Anaesthesia & Intensive Care Medicine Author(s): Sina Kafiabadi, Prem Rangi Plain radiographs continue to play an important role in the assessment of the cervical spine, despite an ever-increasing uptake of cross sectional imaging. They are widely available and utilized in the setting of trauma to assess for cervical spine injury and stability as an integral part of the trauma series. Furthermore they can provide vital information such as dynamic stability in patients with underlying rheumatological conditions, most importantly rheumatoid arthritis. A systematic approach in analysing cervical spine radiographs can be used to glean important information regarding any underlying injury or instability, initiating further steps in the patient's management and crucially allowing the anaesthetist to take precautions in airway management. We outline some of the most important principles of reviewing such radiographs in the adult population in this article and also aim to outline some of the common pitfalls and limitations of assessing such studies in common practice. Finally we briefly review NICE guidelines on the imaging of cervical spine trauma.
Abstract OBJECTIVES: Evaluate the relationship between arthritis diagnosis in those over 50 and exposure to extreme air pollution in utero or infancy (
ConclusionGEN inhibits IL-6–induced VEGF expression and angiogenesis partially through the JAK2/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA.The translational potential of this articleOur study provides scientific guidance for the clinical translational research of GEN in the RA treatment.
Authors: Strand V, Shah R, Atzinger C, Zhou J, Clewell J, Ganguli A, Tundia N Abstract Objective: Determine healthcare resource utilization (HCRU) and associated costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA). Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large U.S. commercial insurance database identified new cases of stiffness/fatigue among newly diagnosed patients. Study patients had ≥2 medical claims for RA ≥45 days apart, continuous insurance coverage ≥12 mont...
Conclusions: Despite individual increases in serum 14-3-3η, HMGB1, anti-CCP, anti-MCV and RF, the combination of anti-CCP and anti-MCV might be of great help for diagnostic in RA, and so should be considered as routine tests for this disease. PMID: 31433746 [PubMed - as supplied by publisher]
ConclusionThis paper demonstrates how the application of causal mediation analyses to randomised trials can identify the mechanisms by which complex interventions exert their effects. We discuss methodological issues and assumptions that should be considered when mediation analyses of randomised trials are used to inform clinical practice and policy decisions.
Conclusion: Our results show for the first time the relationship between serum levels of galectin and the clinical parameters of patients with RA. Demonstrating their role in pathogenesis, new studies with galectins are needed to assess how they function as a biomarker in RA. PMID: 31428469 [PubMed]
Introduction: Less than 10 cases of cutaneous panniculitides have been reported as adverse reactions to abatacept, with the most common reactions associated with oral contraceptives, nonsteroidal antiinflammatory drugs, antibiotics, and leukotriene-modifying agents. It is vital to recognize panniculitis drug reactions in rheumatologic patients for their future treatment options and the current understanding of cutaneous panniculitides associated with medications.
Cutaneous infections with Mycobacterium haemophilum are rare and usually characterized by tender, erythematous, ulcerating skin nodules. The risk of disease from nontuberculosis mycobacterium increases with progressive immunodeficiency. Here, we report a case of cutaneous mycobacterium infection in a patient on chronic immunosuppression for mixed connective tissue disease (MCTD)/interstitial lung disease (ILD). Our patient was receiving azathioprine, hydroxychloroquine sulfate (Plaquenil), and prednisone for MCTD, ILD, and rheumatoid arthritis.
Pyoderma gangrenosum (PG) is a sterile, idiopathic, ulcerative, neutrophilic dermatosis that can be associated with trauma or systemic diseases. The lesion typically begins as a pustule that later progresses to an ulcer or deep erosion with violaceous undermined borders. Diagnosis of PG is based on histopathology as well as exclusion of other diagnoses. Approximately 50% of PG cases are associated with systemic diseases, which include inflammatory bowel disease (IBD), rheumatoid arthritis, and hematologic malignancies.