Personalized therapy helped women with advanced cervical cancer

CHICAGO (Reuters) - A new type of personalized cancer therapy in which immune cells are harvested from patients' tumors, grown in the lab and infused back into patients showed dramatic results in a small, government-led trial in women with advanced cervical cancer, U.S. researchers said on Monday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Authors: Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA Abstract People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has le...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Authors: Hasson SS, H Al-Shubi AS, Al-Busaidi JZ, Al-Balushi MS, Hakkim FL, Rashan L, Aleemallah GM, Al-Jabri AA Abstract Breast and cervical cancers are global health concerns and major cause of deaths among women. Current treatments such as chemotherapy are associated with several drawbacks that limit their effectiveness. Several anticancer remedies have been found with natural products in the past and the search continues for more examples. Cytotoxic natural compounds may have considerable benefits for cancer therapy either in potentiating the impact of chemotherapy or curtailment of harmful effects. Therefore, ...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Abstract The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexu...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
Authors: Abstract The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexu...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
In conclusion, combining MMC with NE-based ESSOs has increased the cytotoxic effect of the MMC on the HeLa cells with different mechanism of actions.Graphical abstract
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Bryan J. Ager, Dolores Gallardo-Rincón, David Cantú de León, Adriana Chávez-Blanco, Linus Chuang, Alfonso Dueñas-González, Eva Gómez-García, Roberto Jerez, Anuja Jhingran, Mary McCormack, Linda Mileshkin, Carlos Pérez-Plasencia, Marie Plante, Andrés Poveda, David K. GaffneyAbstractCervical cancer is the fourth most common cancer in women with 85% of the mortality burden occurring in less-developed regions of the world. The Cervix Cancer Research Network (CCRN) was foun...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
In conclusion, combining MMC with NE-based ESSOs has increased the cytotoxic effect of the MMC on the HeLa cells with different mechanism of actions.Graphical abstract
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Bryan J. Ager, Dolores Gallardo-Rincón, David Cantú de León, Adriana Chávez-Blanco, Linus Chuang, Alfonso Dueñas-González, Eva Gómez-García, Roberto Jerez, Anuja Jhingran, Mary McCormack, Linda Mileshkin, Carlos Pérez-Plasencia, Marie Plante, Andrés Poveda, David K. GaffneyAbstractCervical cancer is the fourth most common cancer in women with 85% of the mortality burden occurring in less-developed regions of the world. The Cervix Cancer Research Network (CCRN) was foun...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Authors: Qu X, Gao D, Ren Q, Jiang X, Bai J, Sheng L Abstract Cervical cancer remains one of the most frequent gynecological malignancies among females around the world. Therefore, fully understanding the molecular mechanisms underlying the progression of cervical cancer may be critical for the development of effective therapeutic strategies against cervical cancer. The object was to evaluate the potential effect of miR-211 and verify its influence on the function of secreted protein acidic and rich in cysteine (SPARC) in cervical cancer. It was demonstrated that miR-211 was downregulated in cervical cancer cell li...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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