Neuroendocrine, Autonomic, and Metabolic Responses to an Orexin Antagonist, Suvorexant, in Psychiatric Patients with Insomnia

Conclusion: Suvorexant treatment resulted in overall improvement in the quality of sleep and the severity of anxiety and depression. This dual orexin antagonist may be related to autonomic functions and neuroendocrine systems, especially in the hypothalamus-pituitary-adrenal axis in psychiatric subjects. Introduction The hypothalamus plays a critical role in the integrated control of sleep/wakefulness, thermogenesis, and energy homeostasis, and the lateral hypothalamus area (LHA) in this region has been regarded as an important center for arousal and feeding.[1] The neuropeptide orexin A and orexin B (also known as hypocretin 1 and hypocretin 2, respectively) were initially identified as endogenous ligands for two orphan G-protein-coupled receptors exclusively expressed in the LHA neurons.[2,3] Orexin-producing neurons (orexin neurons) project their axons throughout the entire brain, excluding the cerebellum,[4,5] which suggests that their functions are varied. Particularly, dense projections of orexin neurons are observed in the serotonergic dorsal raphe nucleus (DR), noradrenergic locus coeruleus (LC), and histaminergic tuberomammillary nucleus (TMN), and all of these nuclei are involved in promoting arousal.[6] On the other hand, orexin neurons receive abundant input from the limbic system and also have reciprocal links with hypothalamic arcuate (Arc) nucleus,[4,7] which regulates feeding behavior. Moreover, the responsiveness of orexin neurons to peripheral metabolic cues...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Current Issue Depression Original Research Psychiatry Psychopharmacology Sleep Disorders Autonomic nervous insomnia neuroendocrine orexin antagonist suvorexant Source Type: research

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Awaken Joy, LLC, Psychiatric Nurse Practitioner, Fairbanks, AK, 99709 | Psychology Today Awaken Joy, LLC, Psychiatric Nurse Practitioner, Fairbanks, AK, 99709, Thank you for your interest. Susana ("Sana") Donofry is a psychiatric nurse practitioner. She prescribes medicine for ADHD and mental health issues like depression, anxiety, and addiction. She accepts most insurance plans... www.psychologytoday.com I was looking at psych profiles in the 20 or so states that allow nurse practitioners to practice independently, it was surprising to s...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
Authors: Lin WC, Tsai JP, Lai YH, Lin YL, Kuo CH, Wang CH, Hsu BG Abstract Osteoprotegerin (OPG) is a potential biomarker of cardiovascular disease complications and severity. Peripheral arterial disease (PAD) is associated with an increased risk of death in patients on peritoneal dialysis (PD). Therefore, this study aimed to evaluate the relationship between serum OPG levels and PAD by measuring the ankle-brachial index (ABI) of patients on PD. A commercial enzyme-linked immunosorbent assay kit was used to measure OPG values. Left or right ABI values of
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
CONCLUSIONS: The interaction and communication between patient and psychiatrist should be improved to capture the need of intervention and to instruct individual supporting measures. PMID: 31952091 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
CONCLUSION: Psychiatric services might consider different priorities referring to work and life and their impact on coping with depression among men. PMID: 31952090 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
CONCLUSIONS: The GSDS-26 is a preliminary validated multidimensional scale for better identifying depression in men and may be suitable for routine use after further validation. PMID: 31952089 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
CONCLUSIONS: Our results stress the relevance of increases in depressive symptoms for upcoming functional decline among the oldest old. Further longitudinal studies are required to replicate our findings. PMID: 31952087 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
CONCLUSION: Shame needs to be viewed in context of gender roles, status, and their interaction. Future studies should investigate the influence of mental health literacy. PMID: 31952086 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
CONCLUSIONS: In the population studied mental illness alone was not a sufficient predictor for suicide. Rather, an interaction between mental illness, psychosocial crisis and other factors may explain and predict suicides. Suicide prevention should better address the needs of relatives and family doctors and offer specific low-threshold services. PMID: 31952085 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
This study has important implications for the future investigations of prevention of periprosthetic infection. The nomogram model identifies high-risk patients for whom attached prophylaxis measures are required. Future studies regarding reduction of incidence of periprosthetic infection should pay close attention to these high-risk patients.Level of evidenceIV, retrospective, cohort study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Conclusion: S-ketamine is more effective for reducing POD for breast cancer patients. PMID: 31948296 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
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