Interleukin-6 pathway blockade as an option for managing refractory cases of crystal arthritis: two cases report

Publication date: Available online 9 May 2017 Source:Joint Bone Spine Author(s): Neus Quilis, Mariano Andrés, Paloma Vela, Eliseo Pascual
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Authors: Blank M, Shoenfeld Y Abstract BACKGROUND: The hygiene theory represents one of the environmental facets that modulate the risk for developing autoimmune diseases. There is a reverse correlation between the presence of helminthes and flares of autoimmune diseases, which explains the rise in incidence of certain autoimmune diseases in developed countries. The protective properties of certain helminthes are attributed to their secretory compounds which immunomodulate the host immune network in order to survive. Thus, the helminthes use an array of mechanisms. One of the major mechanisms enabling manipulation ...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Conditions:   Rheumatoid Arthritis;   Psoriasis;   Heart Failure Intervention:   Behavioral: Mind-Body Approaches for Medical Conditions Sponsors:   University Hospital, Gentofte, Copenhagen;   Department of Rheumatology, Aarhus University Hospital, Denmark;   Department of Cardiology, Odense University Hospital, University of Southern Denmark;   Department of psychology, University of Copenhagen;   Musculoskeletal Statistics Unit, Th e Parker Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Galectin-3 may have potential as a biomarker for the early onset of cardiovascular disease in RA patients, potentially enabling early intervention and deferring the cardiovascular risks associated with RA...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis cardiovascular Cardiovascular disease galectin‐3 Rheumatoid Arthritis (RA) risk Source Type: research
New research does not support the use of a magnetic resonance imaging (MRI)-guided strategy for treating RA patients. The study found that among RA patients in remission, an MRI-guided treat-to-target strategy compared with a conventional treat-to-target strategy did not result in improved disease activity remission rates or reduced radiographic progression...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis Magnetic resonance imaging (MRI) Rheumatoid Arthritis (RA) Source Type: research
In conclusion, the optimized MTX nanogel formulation displayed skin biocompatibility, sustained systemic delivery, safety as well as therapeutic efficacy.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The vast majority of patients with systemic lupus erythematosus (SLE) complain about fatigue. They also report fatigue as one of their most debilitating symptoms. Yet, in clinical practice, fatigue is only rar...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
AbstractBackgroundIt is not established beyond doubt whether improvements in functional outcome after total knee arthroplasty (TKA) are maintained in the long term. We therefore investigated the temporal patterns of functional outcome [using range of motion (ROM), American Knee Society (AKS) score, Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, and 36-Item Short Form Health Survey (SF-36) score] over a 5-year period after uncomplicated TKA, and whether these patterns differed by implant type and patient age.Materials and methodsThis prospective study evaluated 138 patients who underwent unilateral...
Source: Journal of Orthopaedics and Traumatology - Category: Orthopaedics Source Type: research
ConclusionA large number of older adults expressed concerns about falling and we also found several factors to be associated with developing FOF, supporting the need for screening. Thus, further research is needed in order to understand the relationship between severity of FOF and actual fall events for developing preventive measures which can be implemented before FOF becomes a problem.
Source: Journal of Public Health - Category: Health Management Source Type: research
Authors: Calabresi E, Monti S, Governato G, Carli L Abstract Spondyloarthritis (SpA) is an inflammatory condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features that genetically tend to be associated with the major histocompatibility complex class 1 antigen, HLA-B27, and in which both peripheral and axial joints might be affected. In addition to arthritis, the typical musculoskeletal manifestations are enthesitis and dactylitis. Extraarticular manifestations such as acute anterior uveitis (AAU), psoriasis (PsO) and inflammatory bowel disease (IBD) are al...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Publication date: Available online 23 March 2019Source: Surgery (Oxford)Author(s): Jonathan P. Evans, Paul GuyverAbstractShoulder arthritis is a painful and functionally limiting condition. Importantly, the overarching diagnosis of shoulder arthritis encompasses a cascade of pathologies affecting the bony and soft tissue structures of the shoulder. Although many surgical and non-surgical management options are available, effective utilization of these treatments is dependent upon careful diagnosis and consideration of the complex anatomy of the glenohumeral joint. This review considers what is known about this increasingly...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
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