Log in to search using one of your social media accounts:

 

In vitro release testing method development for ophthalmic ointments

Publication date: 30 June 2017 Source:International Journal of Pharmaceutics, Volume 526, Issues 1–2 Author(s): Quanying Bao, Jie Shen, Rajan Jog, Carmen Zhang, Bryan Newman, Yan Wang, Stephanie Choi, Diane J. Burgess It is essential as well as challenging to develop a reliable in vitro release testing method for determining whether differences in release profiles exist between qualitatively and quantitatively equivalent ophthalmic ointment formulations. There is a lack of regulatory guidance on in vitro release testing methods for ophthalmic formulations. Three different in vitro release testing methods 1) USP apparatus 4 with semisolid adapters; 2) USP apparatus 2 with enhancer cells; and 3) Franz diffusion cells were investigated. Qualitatively and quantitatively equivalent ointments were prepared via hot melting and simple mixing methods using four different sources of excipients (i.e. white petrolatum). The ointment formulations were characterized for content uniformity, particle size, and rheological parameters. All the formulations showed adequate content uniformity and similar particle size. The ointments prepared via the hot melting processes showed higher rheological parameters, as did the ointments prepared using ‘white’ petrolatum that exhibited a yellowish color. The three in vitro release testing methods were compared and evaluated for reproducibility, discriminatory capability, and correlation with the rheological parameters. Compared with th...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

Related Links:

Abstract “I have noticed in operations of this kind, which I have seen performed by others upon the living, and in a number of excisions, which I have myself performed on the dead body, that most of the difficulty in the separation of the tumor has occurred in the region of these ligaments…. This difficulty, I believe, to be a very frequent source of that accident, which so commonly occurs in removal of goiter, I mean division of the recurrent laryngeal nerve.” Sir James Berry (1887)
Source: Head and Neck - Category: ENT & OMF Authors: Tags: PRACTICE GUIDELINES Source Type: research
Conclusion: The anatomical relationship between the infraorbital nerve and postoperative maxillary cysts varied among patients, with approximately one-fourth of the patients being at risk of infraorbital nerve injury even during endoscopic procedures.ORL 2018;80:28 –35
Source: ORL - Category: ENT & OMF Source Type: research
Paula G. Slater, Sebastian E. Gutierrez-Maldonado, Katia Gysling, Carlos F. Lagos
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract AimsTo identify gestational diabetes mellitus exposure‐associated DNA methylation changes and assess whether such changes are also associated with adiposity‐related outcomes. MethodsWe performed an epigenome‐wide association analysis, using Illumina 450k methylation arrays, on whole blood collected, on average, at 10.5 years of age from 81 gestational diabetes‐exposed and 81 unexposed offspring enrolled in the EPOCH (Exploring Perinatal Outcomes in Children) study, and on the cord blood of 31 gestational diabetes‐exposed and 64 unexposed offspring enrolled in our own ‘Healthy Start’ cohort. V...
Source: Diabetic Medicine - Category: Endocrinology Authors: Tags: Research Article Source Type: research
Summary Naevus sebaceous (NS) is a congenital cutaneous hamartoma, which typically occurs on the head and neck. Historically, the treatment of choice was excision in infancy because of the potential for malignant transformation; however, recent studies suggest that this risk is
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Concise Report Source Type: research
(MedPage Today) -- Peter Ubel, MD, explains how to let older patients know tests won't help
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
(MedPage Today) -- No higher risk of infant hospitalization, death linked to vaccines in pregnancy
Source: MedPage Today Infectious Disease - Category: Infectious Diseases Source Type: news
Authors: PMID: 29457548 [PubMed - in process]
Source: Disability and Rehabilitation. Assistive Technology. - Category: Rehabilitation Tags: Disabil Rehabil Assist Technol Source Type: research
In the early 20th century, botanist David Fairchild traveled the world and brought plants back to the U.S. that we now see as thoroughly American. NPR talks with the author of a book on Fairchild.
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Federal prosecutors say 10 doctors have been charged with overprescribing prescription pain pills from clinics in West Virginia and Virginia
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
More News: Drugs & Pharmacology | Opthalmology